Results 61 to 70 of about 1,234,477 (312)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Italian Political Science, 2023 One of the most significant phenomena in contemporary politics is personalization. Several studies have shown that voters are more influenced by the characteristics of leaders and/or candidates than in the past.
Matteo Boldrini
doaj
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017 The article deals with one of the poorly studied fragments of Russian history – elections of deputies of the USSR Supreme Council and the BSSR Supreme Council for Western Belarus.
Aleksandr V. Kuryanovich
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
"Why Do Political Action Committees Give Money to Candidates? Campaign Contributions, Policy Choices, and Election Outcomes" [PDF]
This paper examines political action committees' motivations for giving campaign contributions to candidates for political office. First, the paper estimates the effect of campaign contributions received by candidates on the outcomes of the 1996 ...
Christopher Magee
core +2 more sources
Frontiers in PsychologyPurposeThe purpose of this study is to investigate whether body shape perceptions and fat phobia differ according to the gender and year of study of PE teacher candidates.
Canan Sayin Temur +3 more
doaj +1 more source
Campaign individualization in a comparative perspective: does the context matter?
Revista da Faculdade de Letras. Série de História, 2019 Despite a great flourishing of studies on election campaigns, the issue of individualized campaigns has been widely neglected, especially from a comparative perspective. Yet, campaigns differ not only in terms of strategy or style, but also with regard
Marco Lisi, José Santana Pereira
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Bias at the Ballot Box? Testing Whether Candidates' Gender Affects Their Vote [PDF]
Using data from all elections to the Australian House of Representatives between 1903 and 2004, we examine the relationship between candidates’ gender and their share of the vote.
Andrew Leigh, Amy King
core