Results 61 to 70 of about 2,949,455 (301)

From the Unitary Patent Package to a Federal EU Patent Law

Perspectives on Federalism, 2018
For the last forty years, the European Union has been pursuing the goal of a unified system of patent law, which would make it possible for an invention to be protected, by EU law, throughout the territory of the Member-States, with a single application.
Almeida Juliana, Costa Guilherme Oliveira e   +1 more
doaj   +1 more source

Cell pyroptosis in health and inflammatory diseases

Cell Death Discovery, 2022
Inflammation is a defense mechanism that can protect the host against microbe invasion. A proper inflammatory response can maintain homeostasis, but continuous inflammation can cause many chronic inflammatory diseases.
Yongqi Wu, Jing Zhang, Sihui Yu, Yan Li, Jinrong Zhu, Kai Zhang, Rongxin Zhang   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Star Cluster Candidates in M81

, 2010
We present a catalog of extended objects in the vicinity of M81 based a set of 24 Hubble Space Telescope Advanced Camera for Surveys (ACS) Wide Field Camera (WFC) F814W (I-band) images. We have found 233 good globular cluster candidates; 92 candidate HII
Brian McLeod, Chandar, Chandar, Chandar, de Vaucouleurs, Driver, Freedman, Jay Strader, Jean P. Brodie, John P. Huchra, Julie B. Nantais, Okoń, Riess, Schröder   +13 more
core   +1 more source

From academia to industry: are doctorate holders ready? [PDF]

, 2014
In policy debates related to innovation potential, the limited mobility from academia to industry is often explained by the supposed mismatch of skills needed in these different settings.
De Boyser, Katrien, De Grande, Hannelore, Van Rossem, Ronan, Vandevelde, Karen   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dream-chasing mindscapes: an inquiry into the psychological change process of postgraduate entrance examination candidates

Frontiers in Psychology
As a pivotal pathway for talent advancement in higher education, the postgraduate entrance examination not only shapes the depth of individuals' academic engagement and the breadth of career development, but also carries candidates' distinctive ...
Chen Xiaoman, Chen Xiaoman, Lu Zihui, Shao Juan   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

As cotas fazem diferença? Ações positivas no parlamento Belga

Opinião Pública, 2003
A Bélgica tem a peculiaridade de ser o único Estado-membro da UE a ter introduzido cotas em sua legislação. O tipo de cota que foi implementada prioriza o número, sem dar atenção a como candidatos masculinos e femininos estão posicionados nas listas dos ...
Mercedes Mateo Diaz
doaj   +1 more source