Results 81 to 90 of about 1,567,650 (332)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The Scope of Authority of Iran's Ordinary Legislator in Determining the Eligibility Conditions for Candidates in the Islamic Consultative Assembly Elections: A Critical Review of the Guardian Council's Approach [PDF]

پژوهش‌نامه حقوق اسلامی
∴ Introduction ∴ ‌In contemporary constitutional democracies, the eligibility criteria for electoral candidates play a crucial role in safeguarding the integrity and effectiveness of legislative bodies.
Mostafa Mansourian, Mohammad Hasan Bagheri Khouzani   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Pain, Disability, Fear -avoidance and Habitual Physical Activity in Subjects with Low Back Pain with and without Trunk and Hips Rotational Demand Sport Activities

مجله پژوهش در علوم توانبخشی, 2014
Introduction: Many factors are related to the disability of subjects with chronic low back pain. Fear-avoidance of injury and movement are the most important risk factors to increase the disability followed by decreased physical activity in these ...
Meissam Sadeghisani, Mohammad Taghi karimi, Mohammad Jafar Shaterzadeh, Ahmad Reza Rafiei, Reza Salehi, Hossein Negahban   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Belgian Candidates in Search of a Constituency

, 2009
Lieven De Winter, Belgian Candidates in Search of a Constituency, paper presented at the Comparative Candidate Survey workshop on “Candidates in Constituency Campaigns in Comparative Perspective”, Cornell University, Ithaca, October 2-3 ...
Candidates in Constituency Campaigns in Comparative Perspective, De Winter, Lieven   +1 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spectral Properties Of Galactic And Extragalactic Black Hole Candidates

, 2007
We review current theoretical understanding of the spectral properties (low and high states, transition of states, quasi-periodic oscillations etc.) of the low mass as well as supermassive black hole candidates.
Sandip Chakrabarti, Hole Candidates, Extragalactic Black   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The selection of parliamentary candidates in Belgium

, 1985
Papier présenté à l'atelier 'The selection of parliamentary candidates' aux Joint Workshops of the European Consortium for Political Research, Barcelona, mars 1985, 32 ...
The selection of parliamentary candidates, De Winter, Lieven   +1 more
core