Results 11 to 20 of about 30,750 (313)

Diagnostic efficiency of inflammatory signatures to distinguish isolated candidemia from candidemia with bacterial co-infection [PDF]

Frontiers in Immunology
IntroductionTo identify the differences in inflammatory response between critically ill patients responding to combined bacterial-fungal sepsis and those with isolated fungal sepsis.MethodsA retrospective case-control study compared ICU patients who were
Magdalena Mnichowska-Polanowska, Bartłomiej Grygorcewicz, Bartłomiej Grygorcewicz, Barbara Dołęgowska, Agnieszka Boroń, Agata Michnowska, Agata Michnowska, Konrad Jarosz, Magdalena Adamowicz, Bartosz Wojciuk   +9 more
doaj   +2 more sources

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

Nature Communications, 2018
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration (MIC) is rarely quantified, and current clinical recommendations suggest it should be ignored.
Iuliana V Ene, Naomi Ziv, Arnaldo Lopes Colombo   +2 more
exaly   +2 more sources

A quality improvement initiative to improve the appropriateness of candidemia management by the implementation of a comprehensive candidemia care bundle at a tertiary care hospital in South India

Medicine, 2022
. Management of candidemia in developing countries like India encounters laxity in appropriate clinical management and challenges in terms of healthcare capacity, despite its association with high morbidity and mortality.
Merlin Moni, MD, Neeraj Sidharthan, DM, Sangita Sudhir, Pharm D, Binny Prabhu, MD, Vrinda Nampoothiri, Pharm D, Jini James, Pharm D, Jeslyn Mary Philip, Pharm D, Jisha Thomas, Pharm D, Remya Antony, Pharm D, Zubair Umer Mohamed, MD, Anil Kumar, MD, Preetha Prasanna, MBA, Fabia Edathadathil, MSc, Sanjeev Singh, MD, PhD, Dipu Sathyapalan, MD, Max Carlos Ramírez-Soto   +15 more
doaj   +2 more sources

Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016–20171

Emerging Infectious Diseases, 2019
Candida auris is an invasive healthcare-associated fungal pathogen. Cases of candidemia, defined as illness in patients with Candida cultured from blood, were detected through national laboratory-based surveillance in South Africa during 2016–2017.
Erika van Schalkwyk, Ruth Mpembe, Juno Thomas, Liliwe Shuping, Husna Ismail, Warren Lowman, Alan Karstaedt, Vindana Chibabhai, Jeannette Wadula, Theunis Avenant, Angeliki Messina, Chetna Govind, K Moodley, Halima Dawood, Praksha Ramjathan, Nelesh P. Govender, for GERMS-SA   +16 more
openalex   +2 more sources

Risk Factors for Candidemia in Intensive Care Unit: A Matched Case Control Study from North-Western India [PDF]

Acta medica, 2022
Candidemia is one of the significant causes of mortality amongst critically ill patients in Intensive Care Units (ICUs). This study aimed to assess the incidence, risk factors and antifungal susceptibility pattern in candidemia cases admitted in ICU in a
Ekadashi Rajni, Ashish Jain, Shilpi Gupta, Yogita Jangid, Rajat Vohra   +4 more
openalex   +2 more sources

Risk Factors and Outcomes of Non-albicans Candida Bloodstream Infection in Patients with Candidemia at Siriraj Hospital—Thailand’s Largest National Tertiary Referral Hospital

Journal of Fungi, 2021
This study aimed to investigate the risk factors for and the outcomes of patients with candidemia caused by non-albicans Candida. Candidemia patients treated at Siriraj Hospital (Bangkok, Thailand) during January 2016 to December 2017 were enrolled.
Chaiyapong Ngamchokwathana, Piriyaporn Chongtrakool, Amiroh Waesamaae, Methee Chayakulkeeree   +3 more
doaj   +2 more sources

Retrospective analysis of mortality and Candida isolates of 75 patients with candidemia: a single hospital experience

Infection and Drug Resistance, 2015
Ryuichi Hirano,1 Yuichi Sakamoto,2 Kumiko Kudo,1 Motoki Ohnishi31Department of Pharmacy, Aomori Prefectural Central Hospital, Aomori, Japan; 2Laboratory Medicine and Blood transfusion, Aomori Prefectural Central Hospital, Aomori, Japan; 3General Medicine,
Hirano R, Sakamoto Y, Kudo K, Ohnishi M
doaj   +3 more sources

P-1951. Utilization of Intensive Care Interventions in Critically Ill Patients with Candidemia vs. Bacteremia: Implications for Empiric Antifungal Prescribing [PDF]

Open Forum Infect Dis
Mary North Jones, Masayuki Nigo, Stefano Casarin, James Kurian, Ankushi Sanghvi, David Enshuo, Stephen Jones, Ashton Connor, B. Corry David, Cesar Andres Diaz Arias, Max Adelman   +10 more
europepmc   +2 more sources

Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity [PDF]

, 2014
Background: Candida albicans infections have become increasingly recognised as being biofilm related. Recent studies have shown that there is a relationship between biofilm formation and poor clinical outcomes in patients infected with biofilm ...
Borghi, Elisa, Falleni, Monica, Jones, Brian, Lappin, David F., Nile, Christopher, Perdoni, Federica, Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann, Smith, Karen, Tosi, Delfina, Williams, Craig   +11 more
core   +19 more sources

Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris: Results from a Phase 2 Trial

Antimicrobial Agents and Chemotherapy, 2023
Fosmanogepix (FMGX), a novel antifungal available in intravenous (IV) and oral formulations, has broad-spectrum activity against pathogenic yeasts and molds, including fungi resistant to standard of care antifungals.
J. Vázquez, P. Pappas, K. Boffard, F. Paruk, P. Bien, M. Tawadrous, E. Ople, P. Wedel, I. Oborska, M. Hodges   +9 more
semanticscholar   +1 more source