Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos +5 more
wiley +1 more source
Invasive candidiasis in the ICU - Pathogenesis and management strategy
How should new and old antifungals be used in the management of invasive candidiasis in ICU patients? A pathogenesis-based management strategy for invasive candidiasis is outlined.
Saunders, G. L., Klugman, K., Lipman, J.
core
Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over-the-Counter Sectors. [PDF]
Gupta AK +4 more
europepmc +1 more source
Expert consensus on oral management in autoimmune bullous diseases, erythema multiforme and SJS/TEN
This international Delphi study achieved expert consensus on 58 statements guiding the management of oral involvement in autoimmune bullous diseases, erythema multiforme and SJS‐TEN. The recommendations emphasize multidisciplinary care, oral hygiene and tailored topical, systemic and inpatient oral management.
Shalini Nayee +39 more
wiley +1 more source
Prevalence and Risk Factors for Oropharyngeal, Esophageal, and Oral Candidiasis in HIV-Positive Individuals: A Systematic Review and Meta-Analysis. [PDF]
Tan XT +3 more
europepmc +1 more source
Tongue pain mapping in 256 patients with lingual burning mouth syndrome identified distinct clinical phenotypes according to pain distribution. Wider pain areas were associated with higher pain intensity and poorer oral health‐related quality of life, supporting individualised assessment and targeted management.
Yoohyun Sim +4 more
wiley +1 more source
A multicenter study on the profile of fungal infections in children infected with HIV in tertiary hospitals in South Western Nigeria. [PDF]
Oyedeji OA +11 more
europepmc +1 more source
Long‐Term Care of OLP Patients: A Retrospective Study From a Single Hospital Outpatient Clinic
ABSTRACT Background Oral lichen planus (OLP) is a chronic immune‐mediated disorder with malignant potential. However, its real‐world clinical course remains incompletely characterized. This study aimed to describe the natural clinical–histopathological trajectory of OLP in a single tertiary centre and to identify factors associated with dysplasia and ...
F. Scilla +8 more
wiley +1 more source
Real‐World Use of Rezafungin for the Treatment of Challenging Aspergillus Infections
ABSTRACT Background Aspergillus infections can pose significant treatment challenges, due in part to increasing triazole resistance. Clinical insight is needed to understand the potential for rezafungin, a next‐generation echinocandin with once‐weekly dosing, to address some limitations of current treatments for Aspergillus infections.
Neil Stone +9 more
wiley +1 more source
French intensive care physicians' practices for the management of high-risk patients with invasive candidiasis: results from the multicenter INSPIRE survey. [PDF]
Dupont H +6 more
europepmc +1 more source

