Results 81 to 90 of about 3,628 (221)

Cangrelor use in a 6-year-old patient undergoing complex percutaneous coronary intervention after post-surgical myocardial infarction

Platelets, 2020
Cangrelor is an intravenously administered P2Y12 receptor antagonist, which has been approved for adult patients undergoing percutaneous coronary intervention and, due to its unique pharmacokinetics, it allows effective and controllable peri-procedural ...
Domenico Sirico, Nuccia Morici, Francesco Soriano, Stefano Maria Marianeschi, Giovanna Pedrazzini, Sergio Leonardi, Gabriele Vignati   +6 more
doaj   +1 more source

Cangrelor Attenuates Coated-Platelet Formation [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2008
P2Y12 inhibitors were introduced clinically as effective inhibitors of adenosine-5′-diphosphate (ADP) mediated platelet activation and aggregation. This class of pharmacological agents has enjoyed considerable success. Cangrelor is a recently developed P2Y12 inhibitor that has the advantage of being an active drug not requiring metabolic conversion ...
Nicholas B, Norgard, Callie L, Hann, George L, Dale   +2 more
openaire   +2 more sources

Novel strategies for assessing platelet reactivity [PDF]

, 2016
There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate
Dovlatova N, Heptinstall S, Heptinstall S, Holm M, Johnson A, Kaplan ZS, Laohathai P, Mohammad Algahtani, Papapanagiotou A, Stan Heptinstall, Zhao L   +10 more
core   +2 more sources

Blood–brain barrier profile pretreatment is associated with hemorrhagic transformation after endovascular reperfusion

Annals of Clinical and Translational Neurology, Volume 11, Issue 12, Page 3292-3299, December 2024.
Abstract Background While advances in endovascular thrombectomy (EVT) have led to high reperfusion rates, most patients treated with EVT do not avoid disability. Post‐reperfusion hemorrhagic transformation (HT) is a potential target for improving outcomes.
Richard Leigh, Pierre Seners, Vanessa Rousseau, Soren Christensen, Jean‐François Albucher, Amel Drif, Christophe Cognard, Adrien Guenego, Alain Viguier, Agnes Sommet, Nicolas Raposo, Lionel Calviere, Anne‐Christine Januel, Michael Mlynash, Fabrice Bonneville, Brice Gaudilliere, Claire Thalamas, Igor Sibon, Thomas Tourdias, Mikael Mazighi, Jeremy J Heit, Benjamin Maier, Gregory W. Albers, Jean‐Marc Olivot, on behalf of the FRAME Investigators   +24 more
wiley   +1 more source

Use of Cangrelor in Patients Undergoing Percutaneous Coronary Intervention: Insights and Outcomes from District General Hospital

Hearts
Background/Objectives: Cangrelor, an intravenous P2Y12 inhibitor, is increasingly used during percutaneous coronary intervention (PCI) for rapid and reversible platelet inhibition in patients unable to take oral antiplatelet agents, particularly in ...
Ibrahim Antoun, Sotirios Dardas, Falik Sher, Mueed Akram, Navid Munir, Georgia R. Layton, Mustafa Zakkar, Kamal Chitkara, Riyaz Somani, Andre Ng   +9 more
doaj   +1 more source

2017 EACTS Guidelines on perioperative medication in adult cardiac surgery [PDF]

, 2017
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesAstraZeneca Boheringer Ingelheim Abbvie Octapharma Orion ...
Castella, Manuel, Collet, Jean-Philippe, Dunning, Joel, Gudbjartsson, Tómas, Head, Stuart J, Jeppsson, Anders, Landmesser*, Ulf, Landoni, Giovanni, Linker, Nick J, Milojevic, Milan, Sandoval, Elena, Sousa-Uva*, Miguel, Thielmann, Matthias   +12 more
core   +2 more sources

Hemin‐induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques

The FEBS Journal, Volume 291, Issue 24, Page 5420-5434, December 2024.
Intraplaque hemorrhages (IPH) result in hemolysis and liberation of iron‐containing heme and its oxidized metabolite, hemin. Hemin activates platelets and has strong prothrombotic activity. Here, we show that agonism of the atypical chemokine receptor 3 (ACKR3) inhibits hemin‐induced platelet activation.
Zoi Laspa, Valerie Dicenta‐Baunach, David Schaale, Manuel Sigle, Ravi Hochuli, Tatsiana Castor, Alp Bayrak, Tobias Harm, Karin Anne Lydia Müller, Thanigaimalai Pillaiyar, Stefan Laufer, Anne‐Katrin Rohlfing, Meinrad Paul Gawaz   +12 more
wiley   +1 more source

Cangrelor in Patients with Percutaneous Coronary Intervention (PCI) After out-of-Hospital Cardiac Arrest (OHCA): A Propensity Score Matchig Analysis

Epidemiology, Biostatistics and Public Health
Introduction: Propensity Score Matching (PSM) is used in observational studies to measure the effect of a treatment by removing the bias of confounders, as randomisation is not possible.
Sara Bendotti , Roberto Primi , Luca Raone , Marco Ferlini , Alessia Currao , Andrea Bongiorno , Cristian Fava , Daniele Ghiraldin , Cinzia Dossena , Andrea Baldo , Diego Maffeo , Vilma Kajana , Silvia Affinito , Leila Ulmanova , Enrico Baldi , Simone Savastano   +15 more
doaj   +1 more source

Acute myocardial infarction complicating ischemic stroke: is there room for cangrelor?

Platelets, 2020
Acute myocardial infarction (AMI) complicating ischemic stroke is a well known and undertreated event. A conservative management is not infrequent in these settings, due to the fear of hemorrhagic complications related to antithrombotic therapy. Notably,
Nuccia Morici, Stefano Nava, Alice Sacco, Giovanna Viola, Jacopo Oreglia, Paolo Meani, Fabrizio Oliva, Marco Ranucci, Sergio Leonardi, Roberta Rossini   +9 more
doaj   +1 more source

Bridging With Low‐Molecular‐Weight Heparin Versus Antiplatelet Therapy in Patients Undergoing Noncardiac Surgery After Percutaneous Coronary Intervention: A Comprehensive Review

Clinical Cardiology, Volume 47, Issue 9, September 2024.
Pros and cons of bridging in noncardiac surgery patients. ABSTRACT Background This review article discussed the use of bridging therapy with low‐molecular‐weight heparin (LMWH) in patients who undergo noncardiac surgery (NCS) after percutaneous coronary intervention (PCI).
Syed Javaid Iqbal, Zulfiqar Qutrio Baloch, Jahanzeb Malik, Nikeeta Bhimani, Amin Mehmoodi, Vishal Gupta   +5 more
wiley   +1 more source