Results 251 to 260 of about 536,577 (345)

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, EarlyView.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

MRI Signal Void in Degenerated Canine Intervertebral Disks May Represent Mineralization or Gas. [PDF]

Vet Radiol Ultrasound
Vali Y, Daniel C, Ludewig E, Schwarz T.
europepmc   +1 more source

A monoclonal antibody, 169.1, against canine leukocyte surface antigen identifies cytoskeletal components in epithelial cells and peripheral neurons.

, 1997
Yukihiko Iwami, Yu Hashimoto, Toshihiko Iwanaga   +2 more
openalex   +2 more sources

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody. [PDF]

Front Vet Sci
Li H, Chen M, Yue R, Li S, Shi B, Qin M, Meng Q, Xie S.   +7 more
europepmc   +1 more source

An experimental study of the ileo-jejunal transposition on the influence of canine gastric acid secretion and gut hormones.

, 1990
Morihiko Toda, Iwao Sasaki, Hiroo Naito, Michinaga Takahashi, Seiki Matsuno   +4 more
openalex   +2 more sources

New Technologies Empower Hemophilic Arthropathy Treatment: Focusing on Regenerative Medicine, Molecular Targeting, and Gene Therapy

Medicine Bulletin, EarlyView.
ABSTRACT Hemophilic arthropathy (HA), a major complication of hemophilia, is a chronic osteoarthropathy driven by repeated joint bleeding. Although traditional therapies such as coagulation factor replacement, physical rehabilitation, and surgery can manage symptoms, they cannot fundamentally repair established joint damage or break the pathological ...
Lin Sun, Yingnan Wang, Leyuan Zhao, Liqiang Lu, Fushan Hou, Chuan Yin, Kun Zhang, Yongqiang Hao, Jingke Fu   +8 more
wiley   +1 more source

Comparative pathophysiology and molecular insights into cutaneous and non-cutaneous canine skin cancers: focus on melanoma, mast cell tumors, and squamous cell carcinoma. [PDF]

Front Immunol
Mârza SM, Munteanu C, Papuc I, Purdoiu RC.   +3 more
europepmc   +1 more source

Asymptotics for the Spectrum of the Laplacian in Thin Bars with Varying Cross Sections

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT We consider spectral problems for the Laplace operator in 3D rod structures with a small cross section of diameter O(ε)$$ O\left(\varepsilon \right) $$, ε$$ \varepsilon $$ being a positive parameter. The boundary conditions are Dirichlet (Neumann, respectively) on the bases of this structure, and Neumann on the lateral boundary.
Pablo Benavent‐Ocejo, Delfina Gómez, Maria‐Eugenia Pérez‐Martínez   +2 more
wiley   +1 more source

History of liver and other splanchnic organ transplantation [PDF]

, 1996
Starzl, TE
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