Down-expression of klotho in canine mammary gland tumors and its prognostic significance
PLoS ONE, 2022 Since the discovery of klotho as an anti-aging gene, its association with tumors has been studied. Several previous studies have reported the down-expression of klotho in various human cancers, and much of its mechanism has been revealed.
Heaji Chung +3 more
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Veterinary Sciences, 2022 Canine mammary tumor (CMT) is the most common tumor in canines after skin tumors. Long noncoding RNAs (lncRNAs) have crucial roles in human breast tumor initiation and progression, but the role of lncRNAs in canine mammary tumors is unclear.
Baochun Lu +4 more
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Protective Effect of HER2 Gene Polymorphism rs24537331 in the Outcome of Canine Mammary Tumors
Animals, 2023 The role of HER2 in canine mammary tumors is not completely elucidated, and the contradictory results published so far may be, in part, explained by the genetic variability recognized in the canine HER2 gene. Single nucleotide polymorphism (SNPs) in HER2
Ana Canadas-Sousa +2 more
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Frontiers in Veterinary Science, 2021 Mammary tumors are the most prevalent neoplasms in non-neutered female dogs, with genetic and epigenetic alterations contributing to canine mammary carcinogenesis.
Luiz Roberto Biondi +4 more
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Presence and importance of oxidative stress parameters in malignant mammary gland tumors in dogs [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 This study aimed to evaluate the presence of oxidative stress based on lipid peroxidation and the DNA damage markers malondialdehyde (MDA) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in canine mammary gland carcinomas using immunohistochemistry techniques ...
Emin KARAKURT +6 more
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Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors
Brazilian Journal of Veterinary Pathology, 2021 Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their significance prognostic is uncertain.
Luciana R. Gomes +5 more
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Evaluation of Cytokeratin 7 Expression in Different Mammary Gland Neoplasms [PDF]
Iranian Journal of Veterinary Medicine, 2021 BACKGROUND: Cytokeratins are non-contractile intermediate filaments engaged in anchoring and structural functions forming a network to support cytoplasm.
Elnaz Elahirad +4 more
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Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. [PDF]
PLoS ONE, 2014 Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study
Ana Gracanin +7 more
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Epidemiological Investigation of Canine Mammary Tumors in Mainland China Between 2017 and 2021
Frontiers in Veterinary Science, 2022 Epidemiological studies enable us to analyze disease behavior, define risk factors, and establish fundamental prognostic criteria. This study aimed to determine the epidemiological and clinical characteristics of canine tumors diagnosed during the years ...
Hui-Hua Zheng +6 more
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Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
Breast Cancer Research, 2023 Background About 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An effective translational model for basal-like breast cancer is currently lacking and urgently needed.
Joshua Watson +6 more
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