Results 61 to 70 of about 70,291 (259)

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Cannabis products and trends in a cohort of young adults: The VapeScan longitudinal study

Tobacco Induced Diseases
Introduction Cannabis is the third most used drug in the world with emerging legalization in the US and other countries. In a descriptive analysis, we report trends in cannabis use and types of products used in the VapeScan longitudinal study, a cohort ...
Katlyn E. McGraw, Elizabeth C. Oelsner, Nancy J. LoIacono, Siyue Gao, William Anderson, Dona Sangapalaarachchi, Vesna Illievski, Justin Liu, Silvia Martins, Tiffany R. Sanchez, Daichi Shimbo, Ana Navas-Acien   +11 more
doaj   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Global epidemiology of cannabis use disorders and its trend from 1990 to 2019: Benchmarking analysis of the global burden of disease study

Journal of Family Medicine and Primary Care
Introduction: Cannabis is one of the most widely used psychoactive substances globally, with an increasing trend in its legalization for both medical and recreational purposes in various countries.
Kinjal Shah, Umm E Farwa, Ankitha Vanaparti, Savan Patel, Manisha Kanumuri, Oshin Vashishth, Nadia Hossain, Roopali Dahiya, Mallareddy Banala, Fredy Reynaldo Pavon Enamorado, Abhiraj S Patel, Huzaifa Nadeem, Ravi Kanani, Hardik D Desai, Kamal H Sharma, Sharanya Tripathi   +15 more
doaj   +1 more source

Implicit associations and explicit expectancies towards cannabis in heavy cannabis users and controls

Frontiers in Psychiatry, 2013
Cognitive biases, including implicit memory associations are thought to play an important role in the development of addictive behaviors. The aim of the present study was to investigate implicit affective memory associations in heavy cannabis users ...
Esther eBeraha, Janna eCousijn, Elisa eHermanides, Anna E Goudriaan, Reinout W Wiers   +4 more
doaj   +1 more source

Epilepsy in emerging adulthood: Clinical, psychosocial, and surgical challenges

Epilepsia, EarlyView.
Abstract Objective Emerging adulthood (EAs; ages 19–29 years) is a unique developmental stage marked by major psychological, social, and occupational transitions. We sought to characterize the clinical, psychosocial, and surgical features of epilepsy in emerging adulthood, considering both current age and age at epilepsy onset.
Graham A. McLeod, Colin B. Josephson, Samuel Wiebe, The Calgary Comprehensive Epilepsy Program Collaborators, Felippe Borlot, Guillermo Delgado‐García, Paolo Federico, Nathalie Jette, Karl Martin Klein, William Murphy, Neelan Pillay, Andrea Salmon, Shaily Singh, The Epilepsy Surgery Satisfaction Questionnaire Study Group, Mark J. Atkinson, Walter J. Hader, Mark R. Keezer, Oluwaseyi A. Lawal, Sophia Macrodimitris, Kristina Malmgren, Dang K. Nguyen, Scott B. Patten, Tolulope T. Sajobi, Ruby Sharma, Yves Starreveld, José Tellez‐Zenteno, Sandra Wahby   +26 more
wiley   +1 more source

Association of cigarette and e-cigarette use with cannabis-related risk perceptions and intentions

Journal of Cannabis Research
Background This study examines the associations of current use of combustible cigarettes or e-cigarettes with perceived risk of cannabis use and intention to use cannabis within the next year.
Ronja Kleine, Barbara Isensee, Frauke Nees, Reiner Hanewinkel   +3 more
doaj   +1 more source

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal, Patrick Landazuri, David E. Burdette, Sanjay Patra, Angela N. Crudele, Dario Englot, Jay R. Gavvala, Sandipan Pati, Lesley C. Kaye, Steven Ojemann, Daniel Barnett, Joseph Neimat, Adriana E. Palade, Shervin Rahimpour, Amir A. Arain, Robert Mark Richardson, Sydney S. Cash, Vicenta Salanova, Alexandra Urban, William P. Welch, Jamie Joseph Van Gompel, Keith Starnes, David Spencer, Lia D. Ernst, Ushtar Amin, Angelica Rivera‐Cruz, Patricia Dugan, Marytery Fajardo, Matt Lallas, Barbara C. Jobst, Nicole Odom, Jarod L. Roland, Jon T. Willie, Sameer A. Sheth, Alica M. Goldman, Christopher T. Skidmore, Chengyuan Wu, Cornelia Drees, Jonathon Parker, Taneeta Mindy Ganguly, Jerzy Szaflarski, Saadi Ghatan, Lise Johnson, Jacob Norman, Brett Wingeier, Cairn G. Seale, Martha J. Morrell, Nautilus Study Group   +47 more
wiley   +1 more source

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

Cannabis use and its association with psychopathological symptoms in a Swiss adult population: a cross-sectional analysis

Frontiers in Public Health
BackgroundAs the most commonly used illicit substance, cannabis is gaining global acceptance through increasing legalization efforts. This shift intensifies the need for research to guide policymakers and healthcare providers in harm reduction and ...
Christoph Felix Mosandl, Christoph Felix Mosandl, Lavinia Baltes-Flückiger, Jens Kronschnabel, Maximilian Meyer, Adrian Guessoum, Oliver Herrmann, Marc Vogel, Marc Walter, Eva-Maria Pichler   +9 more
doaj   +1 more source