Results 231 to 240 of about 31,819 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Williams Pear Canning-Industrial Residues Suitable for Powdered Products: Effect of Particle Size and Acid Immersion on Physicochemical and Bioactive Properties. [PDF]

Foods
Gomez Mattson M, Diez S, Sette P, Corfield R, Garrido Makinistian F, Schebor C, Franceschinis L, Salvatori DM.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Processed fish products: a protein source for humans and the challenges faced in processing. [PDF]

J Food Sci Technol
Kharl MWM, Hussain SM, Ali S, Nazish N, Ghafoor A, Alshehri MA, Naeem A, Naeem E, Amjad M, Yilmaz E.   +9 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough. [PDF]

Physiol Rep
Brown JC, Rhatigan KL, Price OJ, Cho PSP.   +3 more
europepmc   +1 more source

Health risk assessment of potentially toxic elements in canned Pinto beans and Fava beans distributed in Gilan Province of Iran. [PDF]

Sci Rep
Valizadeh Moghadam Jirandehi H, Nourieh N, Yazdanfar N, Kashi G.   +3 more
europepmc   +1 more source

Emerging Strategies Targeting the PI3K/AKT/mTOR Pathway in HR+/HER2- Advanced Breast Cancer. [PDF]

Drugs
Lei L, Canning M, Sakach E, Lateef A, Kamga L, Abid M, Kalinsky K, Gandhi S.   +7 more
europepmc   +1 more source

Comparison of CD4 T-Cell Response in Plasmodium falciparum and vivax Malaria. [PDF]

J Infect Dis
Nalubega M, Soon MSF, Andrew D, Ortega-Pajares A, Canning J, Dooley N, Loughland JR, Engwerda C, Kenangalem E, Price RN, Minigo G, Anstey NM, Oyong DA, Boyle MJ.   +13 more
europepmc   +1 more source

Regioselectivity Study of Contrasteric Aromatic Claisen Rearrangements and Their Utilization in the Total Syntheses of 5-Hydroxymellein and Botyroisocoumarin A. [PDF]

J Org Chem
Tanas DK, Li R, Khan HH, Johnson TC, Brown LE, West PM, Guin EJ, Jones SE, Garci NK, Canning DM, Ramirez EJ, Sekhon GS, Pierce TH, Ustoyev A, Croatt MP.   +14 more
europepmc   +1 more source