Results 61 to 70 of about 45,603 (231)

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Is the pull-out force of the Meniscus Arrow in bone affected by the inward curling of the barbs during biodegradation? An in vitro study [PDF]

, 2009
Background: Inward curling of the barbs of Meniscus Arrows during degradation was observed in a previous study, in which swelling, distention, and water uptake by Meniscus Arrows was evaluated.
Bos, R.R.M., de Hosson, J.T.M., Wouters, D.B., Burgerhof, J.G.M.   +3 more
core  

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Outcome of Patellar Fractures Fixation Using Cannulated Screws with Tension Band Wiring [PDF]

Zagazig University Medical Journal
Background: Several techniques were utilized for internal fixation of patellar fractures which include the AO modified tension band wiring, interfragmentary screws or figure of eight wiring using the cannulated screws.
Sameh Holyl, Ahmed Eletawy Soudy, Hossam Khiry, Hossam Mahmoud   +3 more
doaj   +1 more source

The Forgotten Joint Score Shows High Correlation With Established Anterior Cruciate Ligament Reconstruction Patient‐Reported Outcome Measures While Capturing Joint Awareness and Functional Recovery: A Systematic Review

Arthroscopy, EarlyView.
Purpose To systematically review and analyze the existing literature on the use of the Forgotten Joint Score‐12 (FJS‐12) in patients undergoing anterior cruciate ligament reconstruction (ACLR), with the aim of evaluating its effectiveness as a complementary tool to traditional patient‐reported outcome measures (PROMs) in assessing postoperative ...
Helena Son, Vincent Yu, Prushoth Vivekanantha, Marc Daniel Bouchard, Kanto Nagai, Sachin Tapasvi, Darren de SA   +6 more
wiley   +1 more source

Significant Clinical Improvements Following Arthroscopic Iliopsoas Fractional Lengthening After Total Hip Arthroplasty: A Prospective Multicenter Study

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To prospectively investigate subjective anterior groin pain, patient‐reported outcome measures, complications, reoperation rates, and hip flexion strength after arthroscopic iliopsoas fractional lengthening. Methods From 2023 to 2025, patients with persistent groin pain after total hip arthroplasty refractory to conservative management ...
Brandon Cabarcas, Sanathan Iyer, Sandeep Yanamala, Jason Ina, Alexander Bishop, Adam V. Daniel, Bruce A. Levy, Mario Hevesi   +7 more
wiley   +1 more source

Complicated sternal dehiscence: reconstruction with plates, cables, and cannulated screws.

, 2009
Sternal dehiscence after median sternotomy can be a challenging problem in case of multiple fractures or infection. For sternal refixation, the principles of rigid plate and screw osteosynthesis gained from orthopedic surgery have been recommended by ...
Voss, B;Bauernschmitt, R;Brockmann, G;Krane, M;Will, A;Lange, R
core   +1 more source

Independent Anatomic Double‐Bundle Anterolateral Ligament Reconstruction Using a Pedicled Gracilis Graft During Anterior Cruciate Ligament Reconstruction

Arthroscopy Techniques, EarlyView.
Abstract Recent studies on the anatomy and biomechanics of the anterolateral ligament (ALL) have highlighted its fundamental role in rotational control of the knee. These findings have led to the integration of its reconstruction into anterior cruciate ligament (ACL) reconstruction strategies, in order to improve management of residual pivot shift and ...
Ibrahim Marzouki, Anthony Viste, Thomas Neri   +2 more
wiley   +1 more source