Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
Safety and efficacy for the treatment of C1 and C2 patients with a new method hemodynamic hybrid Nd YAG 1064 LASER and cryosclerotherapy. [PDF]
J Vasc Surg Venous Lymphat DisordSathler de Melo CC, Faccini FP.
europepmc +1 more source
Keeping Mud Off the Bench: The First Amendment and Regulation of Candidates’ False or Misleading Statements in Judicial Elections [PDF]
, 2001 Long, Adam R.
core +1 more source
Advanced Science, EarlyView.Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck +8 more
wiley +1 more source
Early prescription of quadruple therapy in acute decompensated heart failure with reduced ejection fraction: A propensity score-matched analysis. [PDF]
ESC Heart FailEcheverría LE +10 more
europepmc +1 more source
Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes
Advanced Science, EarlyView.Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji +12 more
wiley +1 more source
Reasoning and reconciliation in twelfth-century Anglo-Norman legal writing. [PDF]
Compara Leg Hist (Hart Publ (Oxf Engl))White SB.
europepmc +1 more source
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Complete mitochondrial genome of the Korean Clawed Salamander <i>Onychodactylus koreanus</i> Min, Poyarkov & Vieites, 2012 (Caudata: Hynobiidae). [PDF]
Mitochondrial DNA B ResourJeong JS +4 more
europepmc +1 more source
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source