Results 131 to 140 of about 299,088 (201)

Complete mitochondrial genome of the Korean Clawed Salamander <i>Onychodactylus koreanus</i> Min, Poyarkov & Vieites, 2012 (Caudata: Hynobiidae). [PDF]

Mitochondrial DNA B Resour
Jeong JS, Jung JH, Kim YJ, Lee SA, Lee KJ.   +4 more
europepmc   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Evaluation of short-course durvalumab combined with dose-dense EC in the neoadjuvant setting for locally advanced luminal B/HER2(-) or triple-negative breast cancer. [PDF]

Breast Cancer Res
Devaux A, Beniuga G, Delrée P, Quaghebeur C, Henry S, Van Bockstal M, Galant C, Lefevre S, Korman D, Verschaeve V, Lonchay C, D'Hondt L, Berlière M, van Marcke C, Delmarcelle S, Mine JM, Müller G, Myant N, Bar I, Haussy S, Merhi A, Petrone D, Coulie PG, Canon JL, Duhoux FP, Carrasco J.   +25 more
europepmc   +1 more source

Contextual theologies in the Old Testament? [PDF]

, 2012
Gerstenberger, Erhard S.
core   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Influence of Comprehensive Pre-Anaesthetic Assessment on ASA Classification and Surgical Cancellations in Dogs and Cats: A Retrospective Observational Study. [PDF]

Vet Sci
Cañón Pérez A, Marti-Scharfhausen Sánchez MLR, Sevilla Ureba A, Hernández Magaña EZ, Viscasillas Monteagudo J, Martínez Albiñana A, Redondo JI.   +6 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Evaluation of potentially toxic elements and ecological risks associated with environmental liabilities in Tacna, Peru. [PDF]

PLoS One
Cáceda Quiroz CJ, Maraza Choque GJ, Fora Quispe GL, Farfan Pajuelo DG, Obando Velarde ED, Chiampo F, Carpio Mamani M.   +6 more
europepmc   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

ORBE II Study: Clinical Characteristics and Outcomes After Treatment with Benralizumab According to Airflow Obstruction Status and Smoking Habit. [PDF]

J Clin Med
Martínez-Rivera C, Blanco-Aparicio M, Casas-Maldonado F, Sánchez-Toril López F, Palop-Cervera M, Cassini LF, Sanchez-Trincado JL, Luzon E, Nuevo J, Secall L, González-Sierra M, Barragán CP, Padilla-Galo A.   +12 more
europepmc   +1 more source