Results 171 to 180 of about 299,088 (201)

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds. [PDF]

J Parasitol Res
Sifontes-Rodríguez S, Meneses-Gómez S, Escalona-Montaño AR, Sánchez-Almaraz DA, Pérez-Olvera O, Cañón Rosas AR, Cruz Bautista PZ, Aguirre-García MM.   +7 more
europepmc   +1 more source

Indications and Proof of Non-Consummation [PDF]

, 1952
Doyle, Joseph B., Harrington, Paul V.
core   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Ultra-high spatial resolution at photon-counting computed tomography: technical insights and sustainable applications in cardiothoracic imaging. [PDF]

Eur Radiol Exp
Occhipinti M, Clemente A, De Gori C, Positano V, Neglia D, Celi S, Meloni A, Berti S, Cademartiri F.   +8 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Computed tomography-based prediction of commissural positions facilitates valve-sparing aortic root replacement. [PDF]

JTCVS Tech
Yamauchi H, Ando M, Ino K, Tsukihara H, Aoyama G, Sakuma I, Ono M.   +6 more
europepmc   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Multicenter, Multinational, and Multivendor Validation of an Artificial Intelligence Application for Acute Cervical Spine Fracture Detection on CT. [PDF]

Diagnostics (Basel)
Sung J, Chang PD, Ayobi A, Cotena M, Roca-Sogorb M, Jang J, Chow DS, Chaibi Y.   +7 more
europepmc   +1 more source

Judge Posner\u27s Dissenting Judicial Oeuvre and the Aesthetics of Canonicity [PDF]

, 2006
Blomquist, Robert F.
core   +3 more sources