Results 181 to 190 of about 299,088 (201)

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Microscopic characterization of level 3 surgical masks in a simulation model of dental care: a preliminary study. [PDF]

BMC Oral Health
Prado M, Pacheco LP, Prado MC, Câmara JVF, de Souza Marski SR, do Nascimento Lunz J, Archanjo B, Achete CA, Simão RA.   +8 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Multicenter evaluation of interpretable AI for coronary artery disease diagnosis from PET biomarkers. [PDF]

NPJ Digit Med
Zhang W, Kwiecinski J, Shanbhag A, Miller RJH, Mostafavi S, Ramirez G, Yi J, Han D, Dey D, Grodecka D, Grodecki K, Lemley M, Kavanagh P, Liang JX, Zhou J, Builoff V, Hainer J, Carre S, Barrett L, Einstein AJ, Knight S, Mason S, Le VT, Acampa W, Wopperer S, Chareonthaitawee P, Berman DS, Di Carli MF, Slomka PJ.   +28 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Beating stress: Evidence for recalibration of word stress perception. [PDF]

Atten Percept Psychophys
Bujok R, Peeters D, Meyer AS, Bosker HR.
europepmc   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

<i>Candida</i> spp. in Denture Stomatitis: Prevalence, Microbial Load, and Antifungal Resistance Across Severity Levels. [PDF]

Microorganisms
Fifolato MA, Clemente LM, Ribeiro AB, Oliveira VC, Salgado HC, Watanabe E, Silva CHLD.   +6 more
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Haptoglobin as a supplement in in vitro embryo culture: a tool for improving bovine embryo development and quality. [PDF]

Biol Res
Cañón-Beltrán K, Cajas YN, Martínez-López C, Moros-Nicolás C, Sòria-Monzó P, Balastegui-Alarcón M, Avilés M, Rizos D, García-Vázquez FA, Izquierdo-Rico MJ.   +9 more
europepmc   +1 more source