Results 31 to 40 of about 7,778 (229)
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
The best of them that speak this speech : language and empire in William Skakespeare`s the tempest [PDF]
, 1996 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e ExpressãoJá em 1486 e 1492, Antonio de Nebrija e o Bispo de Ávila, bem como Nicolò Maquiavel, em 1513, perceberam a relação entre linguagem e império.
Lopes, Sebastião Alves Teixeira
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Tradução comentada de a Sentimental Journey de Laurence Sterne [PDF]
, 2007 Tese (doutorado) - Universidade Federal Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Literatura.Este trabalho parte da tradução de A Sentimental Journey, de Laurence Sterne, para fazer um exame de questões ligadas à ...
Freitas, Luana Ferreira de
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Estudo da remoção biológica de nitrogênio a partir de lodo nitrificante cultivado em meio autotrófico sob condições anóxicas [PDF]
, 2004 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia Química.O descarte de efluentes contendo concentrações elevadas de nitrogênio, pode comprometer o equilíbrio ambiental, causando ...
Kieling, Dirlei Diedrich
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, 2023 El ser humano se encuentra constantemente en la búsqueda de sentido sobre los elementos que le rodean con la pretensión de dar un significado a la vida misma; la literatura no es ajena a estos espacios y, desde sus letras, otorga una respuesta a aquellas
Orjuela Riaño, María Fernanda
core +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source