Results 241 to 250 of about 204,625 (300)

On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations. [PDF]

Commun Biol
Helmer M, Warrington S, Mohammadi-Nejad AR, Ji JL, Howell A, Rosand B, Anticevic A, Sotiropoulos SN, Murray JD.   +8 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Identifying genes associated with disease outcomes using joint sparse canonical correlation analysis-An application in renal clear cell carcinoma. [PDF]

Genet Epidemiol
Dutta D, Sen A, Satagopan JM, Satagopan JM.   +3 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Multimodal data fusion using sparse canonical correlation analysis and cooperative learning: a COVID-19 cohort study. [PDF]

NPJ Digit Med
Er AG, Ding DY, Er B, Uzun M, Cakmak M, Sadee C, Durhan G, Ozmen MN, Tanriover MD, Topeli A, Aydin Son Y, Tibshirani R, Unal S, Gevaert O.   +13 more
europepmc   +1 more source

Classifying breast cancer subtypes on multi-omics data via sparse canonical correlation analysis and deep learning. [PDF]

BMC Bioinformatics
Huang Y, Zeng P, Zhong C.
europepmc   +1 more source

Canonical correlation analysis of family burden of disease and quality of life in caregivers of people living with schizophrenia: evidence from Schizophrenia-specific cohort in the less-developed multi-ethnic region of Southwest China. [PDF]

BMC Psychiatry
Wang X, Zhang T, Li M, Yang B, Wang L, Fu C, Zhang N, Li Z, Yang C, Zhao Z, Meng Q, Feng Y, Yin J.   +12 more
europepmc   +1 more source

Penalized canonical correlation analysis reveals a relationship between temperament traits and brain oscillations during mind wandering. [PDF]

Brain Behav
Heinilä E, Hyvärinen A, Parkkonen L, Parviainen T.   +3 more
europepmc   +1 more source