Results 241 to 250 of about 1,105,140 (302)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Physiological pathways linking body conformation and reproductive efficiency in Murciano-Granadina does: A novel regularized canonical correlation perspective. [PDF]

Vet Anim Sci
Peláez Caro MP, Arando Arbulu A, León Jurado JM, Delgado Bermejo JV, Fernández Álvarez J, Navas González FJ.   +5 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The functional neurobiology of dispositions towards negative emotions. [PDF]

Nat Commun
Sicorello M, Gianaros PJ, Wright AGC, Petre B, Kraynak TE, Manuck SB, Schmahl C, Wager TD.   +7 more
europepmc   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

Semantic control across Alzheimer's disease phenotypes: cognitive mechanisms and neural correlates. [PDF]

Front Aging Neurosci
Armas P, Morcillo-Nieto AO, Zsadanyi SE, Marques-Kiderle SK, Filella-Mercè J, Ciongoli F, Sala I, Sanchez-Saudinos MB, Rubio-Guerra S, Zhu N, Barroeta I, Carmona-Iragui M, Illán-Gala I, Alcolea D, Lleo A, Fortea J, Grasso SM, Calabria M, Hernando J, Jefferies E, Lambon Ralph MA, Binney RJ, Bejanin A, Santos-Santos MA.   +23 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Machine learning framework for depression subtype grouping: integrating high-resolution imaging and clinical symptom analysis via correlation and clustering. [PDF]

Front Psychiatry
Verma G, Jacob Y, Morris LS, Xing X, Delman BN, Murrough JW, Lin AL, Balchandani P.   +7 more
europepmc   +1 more source

Association between COVID-19 infection experience and physical activity levels in post-recovery college students. [PDF]

Front Public Health
Guan Z, Wu Y, Liu G, You M.
europepmc   +1 more source

Revealing the Shared Genetic Architecture of Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Traits Through Genomic Structural Equation Modeling. [PDF]

Genet Epidemiol
Dong H, Li Y, Ding Q, Zhang M, Gu S, Liu M.   +5 more
europepmc   +1 more source