Results 51 to 60 of about 1,105,140 (302)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multivariate relationship among pH, subcutaneous fat thickness, and color in bovine meat using canonical correlation analysis

Revista Colombiana de Ciencias Pecuarias, 2020
Background: pH, subcutaneous fat thickness (SFT), and color are fundamental variables to define the organoleptic characteristics of meat. However, multivariate relationships of those traits remain unexplored in bovine meat.
Julián A. C. Vargas, João E. de S. Coutinho, Daiany I. Gomes, Kaliandra S. Alves, Raylon P. Maciel, Rafael Mezzomo   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Learning Canonical Correlations

, 1995
This paper presents a novel learning algorithm that finds the linear combination of one set of multi-dimensional variates that is the best predictor, and at the same time finds the linear combination of another set which is the most predictable.
Borga, Magnus, Landelius, Tomas, Knutsson, Hans   +2 more
core   +2 more sources

yaImpute: An R Package for kNN Imputation

Journal of Statistical Software, 2007
Canonical correlations analysis (CCA) is an exploratory statistical method to highlight correlations between two data sets acquired on the same experimental units.
Pascal G. P. Martin, Alain Baccini, Sébastien Déjean, Ignacio González   +3 more
doaj  

Canonical correlation analysis for studying the relationship between egg production traits and body weight, egg weight and age at sexual maturity in layers

Czech Journal of Animal Science, 2005
In this study, canonical correlation analysis was applied to layer data to estimate the relationships of egg production with age at sexual maturity, body weight and egg weight.
Y. Akbaş, Ç. Takma
doaj   +1 more source

Multivariate approach for studying interactions between environmental variables and microbial communities. [PDF]

PLoS ONE, 2012
To understand the role of human microbiota in health and disease, we need to study effects of environmental and other epidemiological variables on the composition of microbial communities.
Xinhui Wang, Marinus J C Eijkemans, Jacco Wallinga, Giske Biesbroek, Krzysztof Trzciński, Elisabeth A M Sanders, Debby Bogaert   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Three denials of time in the interpretation of canonical gravity [PDF]

, 2011
The analysis of the temporal structure of canonical general relativity and the connected interpretational questions with regard to the role of time within the theory both rest upon the need to respect the fundamentally dual role of the Hamiltonian ...
Thebault, Karim P Y, Karim P Y Thébault
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source