Results 41 to 50 of about 29,917 (203)
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Reduction Numbers and Balanced Ideals [PDF]
, 2012 Let $R$ be a Noetherian local ring and let $I$ be an ideal in $R$. The ideal $I$ is called balanced if the colon ideal $J:I$ is independent of the choice of the minimal reduction $J$ of $I$.
Fouli, Louiza
core
The variety of reductions for a reductive symmetric pair
, 2010 We define and study the variety of reductions for a reductive symmetric pair (G,theta), which is the natural compactification of the set of the Cartan subspaces of the symmetric pair.
Grünewald, Michaël Le Barbier
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Bihamiltonian Reductions and W_n Algebras
, 1997 We discuss the geometry of the Marsden-Ratiu reduction theorem for a bihamiltonian manifold. We consider the case of the manifolds associated with the Gel'fand-Dickey theory, i.e., loop algebras over sl(n+1).
Abraham +35 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Hirota equation and the quantum plane
, 2012 We discuss geometric integrability of Hirota's discrete KP equation in the framework of projective geometry over division rings using the recently introduced notion of Desargues maps.
Doliwa, Adam
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung +7 more
wiley +1 more source
Extension of the Adler-Bobenko-Suris classification of integrable lattice equations
, 2007 The classification of lattice equations that are integrable in the sense of higher-dimensional consistency is extended by allowing directed edges. We find two cases that are not transformable via the 'admissible transformations' to the lattice equations ...
Bobenko A I +5 more
core +3 more sources
TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara +18 more
wiley +1 more source