Results 121 to 130 of about 1,601,992 (295)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Canonical Higher-Order Kernels for Density Derivative Estimation [PDF]

In this note we present r th order kernel density derivative estimators using canonical higher-order kernels. These canonical rescalings uncouple the choice of kernel and scale factor. This approach is useful for selection of the order of the kernel in a
Christopher F. Parmeter, Daniel J. Henderson   +1 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

PerseusDL/canonical-latinLit: 0.0.8990715730

XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Jacob Wegner, Tamas Bolner, Alison Babeu, Stella, Bridget Almas, Matthew Munson, helmadik, Thibault Clérice, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +21 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Canonical Extensive Form of a Game Form - Part II - Representation [PDF]

This paper exhibits to any noncooperative game in strategic or normal form a 'canonical' game in extensive form that preserves all symmetries of the former one.
Bezalel Peleg, Peter Sudhölter, Joachim Rosenmüller   +2 more
core  

PerseusDL/canonical-latinLit: 0.0.7952332906

XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Jacob Wegner, Alison Babeu, Stella, Bridget Almas, Matthew Munson, helmadik, Thibault Clérice, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +20 more
core   +1 more source

DE-MYTHOLOGIZING THE BARD: APPROPRIATION OF SHAKESPEARE IN TOM STOPPARD’S DOGG’S HAMLET, CAHOOT’S MACBETH [PDF]

Logos et Littera: Interdisciplinary Approaches to Text, 2014
One of the most entrenched myths that dramatic authors need to contest and adjust to is the Shakespeare myth, a long-lasting and all-pervasive influence that Shakespeare’s name and texts have exerted since the late 16th century, being perceived as ...
Ifeta Ciric-Fazlija
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source