Results 81 to 90 of about 1,601,992 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Canonical analysis based on scatter matrices. [PDF]

In this paper, the influence functions and limiting distributions of the canonical correlations and coefficients based on affine equivariant scatter matrices are developed for elliptically symmetric distributions.
Croux, Christophe, Kankainen, A, Taskinen, S, Ollila, E, Ona, H   +4 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

REPRESENTATION-CONSTRAINED CANONICAL CORRELATION-ANALYSIS: A HYBRIDIZATION OF CANONICAL CORRELATION AND PRINCIPAL COMPONENT ANALYSIS [PDF]

The classical canonical correlation analysis is extremely greedy to maximize the squared correlation between two sets of variables. As a result, if one of the variables in the dataset-1 is very highly correlated with another variable in the dataset-2 ...
Sudhanshu K MISHRA
core  

PerseusDL/canonical-latinLit: 0.0.6788730216

, 2023
XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Jacob Wegner, Alison Babeu, Stella, Bridget Almas, Matthew Munson, helmadik, Thibault Clérice, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +20 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PerseusDL/canonical-latinLit: 0.0.3380602595

, 2022
XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Jacob Wegner, Alison Babeu, Stella, Bridget Almas, Matthew Munson, Thibault Clérice, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +19 more
core   +1 more source

Forward and Reverse Gematria are Very Different Beasts

Open Theology
Though a relatively quiet minority, some commentators since the eighth-century Bede have suggested that the notorious “666” of Revelation 13:18 alludes to the measurement of King Solomon’s excessive gold accumulation which immediately precedes his ...
Harris Zachary
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

PerseusDL/canonical-latinLit: 0.0.5728893694

, 2023
XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Jacob Wegner, Alison Babeu, Stella, Bridget Almas, Matthew Munson, helmadik, Thibault Clérice, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +20 more
core   +1 more source