Results 61 to 70 of about 353,133 (282)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Anthroponyms of Jewish Women in the 16th Century Grand Duchy of Lithuania

Respectus Philologicus, 2012
The most popular names among Jewish women in 16th century Lithuania were Simcha, Marjam, Anna, Debora. The names were most frequently recorded as diminutives (63.3%), with only 36.4% appearing in canonical forms. The smallest group comprises names formed
Jūratė Čirūnaitė
doaj   +1 more source

Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site. [PDF]

PLoS ONE, 2011
Pub1p, a highly abundant poly(A)+ mRNA binding protein in Saccharomyces cerevisiae, influences the stability and translational control of many cellular transcripts, particularly under some types of environmental stresses.
Clara M Santiveri, Yasmina Mirassou, Palma Rico-Lastres, Santiago Martínez-Lumbreras, José Manuel Pérez-Cañadillas   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

“If You Can Change Your Name, You Can Write”: Pseudepigraphy in Antiquity and Its Function in 1 Apocryphal Apocalypse of John

Religions
This article attempts to answer the following question: why did the author of the apocryphon called 1 Apocryphal Apocalypse of John choose to efface himself and adopt John as his pseudonym? Why not Peter or Paul?
Cristian Daniel Cardozo Mindiola
doaj   +1 more source

Graph Abstraction and Abstract Graph Transformation [PDF]

, 2007
Many important systems like concurrent heap-manipulating programs, communication networks, or distributed algorithms are hard to verify due to their inherent dynamics and unboundedness.
Bauer, J., Boneva, I.B., Kurban, M.E., Rensink, A.   +3 more
core   +1 more source

Conjunctive Query Answering for the Description Logic SHIQ

, 2011
Conjunctive queries play an important role as an expressive query language for Description Logics (DLs). Although modern DLs usually provide for transitive roles, conjunctive query answering over DL knowledge bases is only poorly understood if transitive
Glimm, Birte, Horrocks, Ian, Lutz, Carsten, Sattler, Ulrike   +3 more
core   +1 more source

Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival [PDF]

mBio, 2016
ABSTRACT Ehrlichia chaffeensis preferentially targets mononuclear phagocytes and survives through a strategy of subverting innate immune defenses, but the mechanisms are unknown. We have shown E. chaffeensis type 1 secreted tandem repeat protein (TRP) effectors are involved in diverse molecular
Taslima T. Lina, Paige S. Dunphy, Tian Luo, Jere W. McBride   +3 more
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

TO THE HISTORY OF THE MOTION OF THE NAME. MODERN VENDORS IN THE NAME OF GOD IN NON-CANONIC ORTHODOX JURISDICTIONS

Globus, 2020
The article is devoted to imyaslavia - a religious and mystical movement in the Russian Orthodox Church, which, having arisen due to theological disputes, soon opposed itself to the canonical Church and left it. The work also examines the figures of modern non-canonical Orthodoxy, who consider themselves the ideological and spiritual successors of the ...
openaire   +1 more source