Results 41 to 50 of about 353,133 (282)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The “Primitive” Cecilia Valdés. A short story by  Cirilio Villaverde. A translation and introduction by Thomas Genova

Latin American Literary Review
: The text is the first English translation of Cirilo Villaverde’s 1839 “primitive” Cecilia Valdés, a short story that the author penned decades before publishing his canonical novel by the same name.
Thomas Genova
doaj   +1 more source

The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor

Pharmacological Research, 2023
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Efflorescence of Caricature by Todd Porterfield (ed.) [PDF]

, 2011
'International, intergenerational, and interdisciplinary' (p. xv) is how Porterfield positions this ambitious collection which analyses caricature between 1759 and 1838. A product of a conference of the same name, the essays it contains fulfil this remit
Baker, James
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Using Canonical Forms for Isomorphism Reduction in Graph-based Model Checking [PDF]

, 2010
Graph isomorphism checking can be used in graph-based model checking to achieve symmetry reduction. Instead of one-to-one comparing the graph representations of states, canonical forms of state graphs can be computed. These canonical forms can be used to
Kant, Gijs
core   +3 more sources

The Hamiltonian of Einstein affine-metric formulation of General Relativity

, 2009
It is shown that the Hamiltonian of the Einstein affine-metric (first order) formulation of General Relativity (GR) leads to a constraint structure that allows the restoration of its unique gauge invariance, four-diffeomorphism, without the need of any ...
A. Einstein, A. Einstein, A. Palatini, A. Palatini, A.M. Frolov, B.S. DeWitt, C. Lanczos, C. Rovelli, C. Rovelli, C. Teitelboim, C. Teitelboim, C. Teitelboim, C. Teitelboim, C.J. Isham, D.G.C. McKeon, D.M. Gitman, E. Witten, F.A.E. Pirani, H. Nicolai, I.A. Nicolić, J. Gomis, J. Gomis, J. Kijowski, J. Pullin, J. Pullin, J. Schwinger, J.A. Wheeler, J.A. Wheeler, J.L. Anderson, J.M. Pons, J.M. Pons, K. Kuchar, K. Sundermeyer, L. Castellani, L. Castellani, L.P. Faddeev, L.P. Faddeev, M. Bañados, M. Ferraris, M. Han, M. Henneaux, M. Henneaux, M. Henneaux, M.O. Katanaev, N. Kiriushcheva, N. Kiriushcheva, N. Kiriushcheva, N. Kiriushcheva, N. Kiriushcheva, N. Kiriushcheva, N.P. Landsman, P. Horava, P. Mukherjee, P. Peldán, P.A.M. Dirac, P.A.M. Dirac, P.A.M. Dirac, P.A.M. Dirac, R. Arnowitt, R. Arnowitt, R. Arnowitt, R. Banerjee, R. Banerjee, R. Stefano Di, S. Samanta, S. V. Kuzmin, S.-D. Poisson, S.V. Kuzmin, S.W. Hawking, T. Jacobson, T. Thiemann, T. Thiemann, V.A. Franke, V.A. Franke   +73 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source