Results 31 to 40 of about 274,693 (175)

Communication subspace dynamics of the canonical olfactory pathway

iScience
Abstract Understanding how different brain areas communicate is crucial for elucidating the mechanisms underlying cognition. A possible way for neural populations to interact is through a communication subspace, a specific region in the state-space enabling the transmission of behaviorally-relevant spiking patterns.
Joaquín González, Pablo Torterolo, Kevin A. Bolding, Adriano BL Tort   +3 more
openaire   +3 more sources

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

PerseusDL/canonical-greekLit: None

, 2021
XML Canonical resources for Greek ...
Jeroen Hellingman, Stephen Scott, Chiara Palladino, Alison Babeu, Bridget Almas, Matthew Munson, srdee, Thibault Clérice, Chris Drymon, Scott Fleischman, Adiel Mittmann, ahanhardt, Joel Kalvesmaki, Lisa Cerrato, Andrei, Eric Sowell, Aurélien Berra, TDBuck, gregorycrane, KATEBHN   +19 more
core   +2 more sources

Progressively shifting patterns of co-modulation among premotor cortex neurons carry dynamically similar signals during action execution and observation

eLife
Neurons in macaque premotor cortex show firing rate modulation whether the subject performs an action or observes another individual performing a similar action.
Zhonghao Zhao, Marc H Schieber
doaj   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

PerseusDL/canonical-latinLit: None

, 2021
XML Canonical resources for Latin ...
Marius Jøhndal, MMernitz, Stephen Scott, Alison Babeu, Stella, Bridget Almas, Matthew Munson, Thibault Clérice, srdee, Patrick J. Burns, maryam-foradi, Neven Jovanović, zachhimes, Samuel J. Huskey, Masoumeh Seydi, Lisa Cerrato, annettegessner, Giuseppe G. A. Celano, mkonieczny9805, TDBuck   +19 more
core   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Clarke Transform: A Lingua Franca for Continuum Robotics

Advanced Intelligent Systems, EarlyView.
Using the Clarke transform, both robot‐dependent mappings are known exactly for kinematic models, leading to a complete chain of transformations between spaces with associated abstraction. This eases the derivation. Therefore, proposing the Clarke transform as a lingua franca and utilizing a practical fact sheet can pave the way for more systematic ...
Reinhard M. Grassmann, Sami Haddadin
wiley   +1 more source