Results 141 to 150 of about 4,608 (205)

Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis.

Reproductive Toxicology, 2023
Cantharidin (CTD) is a chemical constituent derived from Mylabris and has good antitumor effects, but its clinical use is restricted by its inherent toxicity. However, few researches have reported its reproductive toxicity and mechanisms. This study aims
Yuanyuan Xiao, Ruxia Liu, Wenchao Tang, Changfu Yang   +3 more
semanticscholar   +1 more source

The Effects of Cantharidin and Cantharidin Derivates on Tumour Cells

Anti-Cancer Agents in Medicinal Chemistry, 2009
Natural product extracts are a rich source of small molecules that display antitumor activity. Cantharidin, in the form of the dried body of the Chinese blister beetles: Mylabris phalerata or M. cichorii, displays antitumor activity and induces apoptosis in many types of tumor cells.
Dongwu, Liu, Zhiwei, Chen
openaire   +2 more sources

Transcriptomic profiling and differential analysis reveal the renal toxicity mechanisms of mice under cantharidin exposure.

Toxicology and Applied Pharmacology, 2023
Cantharidin (CTD), extracted from the traditional Chinese medicine mylabris, has shown significant curative effects against a variety of tumors, but its clinical application is limited by its high toxicity.
Xin Liu, Linghan Zhang, Wenchao Tang, Tingting Zhang, Ping Xiang, Qin Shen, Taotao Ye, Yuanyuan Xiao   +7 more
semanticscholar   +1 more source

Cantharidin Induces Pyroptosis in Triple-Negative Breast Cancer Cells via Vitamin D Receptor-Targeted Inhibition and Activation of ROS/Caspase/GSDME Axis.

European Journal of Pharmacology
Cantharidin, a natural small-molecule compound with anticancer activity, has been reported to induce programmed cell death in various cancers. However, its molecular targets in triple-negative breast cancer (TNBC) remain unclear.
Lianghong Zhou, Peng Zhao, Ting Zhou, Meijun Chen, Zili Feng, Yang Pan, Feng Xiao, Xiaojiang Hao, Hui Song, Jue Yang   +9 more
semanticscholar   +1 more source

Bibliometric Analysis and Systemic Review of Cantharidin Research Worldwide.

Current Pharmaceutical Biotechnology, 2023
BACKGROUND Cantharidin (CTD), a natural toxic compound from blister beetle Mylabris, has been used for cancer treatment for millenary. CTD and its analogs have become mainstream adjuvant drugs with radiotherapy and chemotherapy in clinical applications ...
Tianmu He, Can-Can Duan, Wenzhong Feng, Jingwen Ao, Dingyang Lu, Xiaofei Li, Jianyong Zhang   +6 more
semanticscholar   +1 more source

Research progress on the biological characteristics and the synthesis pathway of cantharidin in the family Meloidae (Insecta: Coleoptera).

Insect Biochemistry and Molecular Biology
Cantharidin, an active compound with well-established clinical efficacy, is a defensive secondary metabolite primarily derived from insects in the Meloidae family.
Qian Sun, Bing Wang, Yingying Xie, Fei Xue, Shuangcheng Ma, Bonian Zhao, Yongqiang Lin   +6 more
semanticscholar   +1 more source

Cantharidin

Chemie in unserer Zeit, 2013
AbstractCantharidin wurde aus getrockneten und pulverisierten Canthariden extrahiert und durch Sublimation gereinigt. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder in der supporting information wiedergegeben. Die NMR‐ sowie die Massenspektren werden eingehend interpretiert und mit theoretischen Berechnungen der 13C chemischen ...
Anna Rudo, Hans‐Ullrich Siehl, Klaus‐Peter Zeller, Stefan Berger, Dieter Sicker   +4 more
openaire   +1 more source

A Comprehensive Review on Ethnopharmacology, Phytochemistry of Mylabris, and Pharmacology of Cantharidin

Chemistry and Biodiversity
Mylabris, the dried body of the Chinese blister beetle, has been utilized in traditional medicine across Asia, Europe, South Africa, and North America for the treatment of tumors, carbuncles, and scrofula.
Huan Guo, Wenshuo Ren, M. Guo, Xia Wu, Qiang Guo   +4 more
semanticscholar   +1 more source

Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity.

Food and Chemical Toxicology, 2022
Mylabris, as a natural product of traditional Chinese medicine (TCM), exhibiting typical antitumor activity, and cantharidin (CTD) is the major bioactive component. However, drug-induced nephrotoxicity (DIN) extremely limited its clinical application. In
Tianmu He, Qiyi Wang, Jingwen Ao, Kuan-Hsin Chen, Xiaofei Li, Jianyong Zhang, Can-Can Duan   +6 more
semanticscholar   +1 more source

Exploring cantharidin and its analogues as anticancer agents: A review.

Current Medicinal Chemistry, 2022
BACKGROUND Cantharidin (CTD) is a highly toxic substance which can be used to treat a variety of cancers. However, the clinical application of CTD is restricted due to the serious side effects.
Shaoting Li, Xufeng Wu, Gang Fan, Kui Du, L. Deng   +4 more
semanticscholar   +1 more source