Results 151 to 160 of about 4,608 (205)

The Detoxification Enzymatic Responses of Plutella xylostella (Lepidoptera: Plutellidae) to Cantharidin

Journal of Economic Entomology, 2022
Plutella xylostella (L.) (Lepidoptera: Plutellidae) is one of the most destructive pests of Brassicaceae vegetables. Cantharidin is an insect-derived defensive toxin, which has been reported to have toxicity to a variety of pests and especially ...
Hong Sun, Pei Wang, Chun Wei, Yifan Li, Yali Zhang   +4 more
semanticscholar   +1 more source

Network toxicology, molecular docking technology, and experimental verification revealed the mechanism of cantharidin-induced testicular injury in mice.

Toxicology and Applied Pharmacology
As a protein kinase inhibitor, cantharidin (CTD) exhibits antitumor activities. However, CTD is highly toxic, thereby limiting clinical applications.
Ruxia Liu, Changfu Yang, Xin Yang, Jia Yu, Wenchao Tang   +4 more
semanticscholar   +1 more source

Mice kidney biometabolic process analysis after cantharidin exposure using widely-targeted metabolomics combined with network pharmacology.

Food and Chemical Toxicology, 2022
Cantharidin (CTD) is a principal bioactive component of traditional Chinese medicine Mylabris used in cancer treatment. However, CTD clinical application is limited due to nephrotoxicity, and the mechanism is unknown.
Tianmu He, Lijuan Xiong, Yixin Zhang, Rong Yan, Ming Yu, Meichen Liu, Liu Liu, Can-Can Duan, Xiaofei Li, Jianyong Zhang   +9 more
semanticscholar   +1 more source

Protective mechanism of Astragalus Polysaccharides against Cantharidin‐induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics

Basic & Clinical Pharmacology & Toxicology, 2021
Cantharidin (CTD) is a promising anticancer drug; however, its dosage is limited by hepatotoxicity. We previously showed that Astragalus polysaccharides (APS) effectively improved chemical liver injury.
Xiao-dan Huang, Wenchao Tang, Chang Lin, Zongge Sa, Mengdan Xu, Jie-min Liu, Lina Wang, Wen Li, Yunzhi Chen, Changfu Yang   +9 more
semanticscholar   +1 more source

A Farnesyl Pyrophosphate Synthase Gene Is Expressed in Fat Body Regulates Cantharidin Synthesis in Male Epicauta impressicornis Blister Beetle.

Journal of Agricultural and Food Chemistry
Blister beetles of Epicauta impressicornis have attracted attention because they contain a large amount of cantharidin (CTD). To date, however, the synthesis and transfer of CTD in adults of E. impressicornis are largely unknown. Here, we showed that the
Zhicheng Zhou, Dingze Mang, G. Smagghe, Yangyang Liu, Yinlin Mu, Lin Yang, Xuewen Wang, Xiangsheng Chen   +7 more
semanticscholar   +1 more source

Synthesis of Cantharidine and desoxycantharidine

Proceedings of the Indian Academy of Sciences - Section A, 1944
A new and simple method for the synthesis of cantharidine and desoxycantharidine has been described.
K. D. Paranjape, N. L. Phalnikar, B. V. Bhide, K. S. Nargund   +3 more
openaire   +1 more source

Treatment of Warts with Cantharidin

Archives of Dermatology, 1958
Warts are viral tumors of the epidermis. They may be destroyed by a great variety of physical and chemical means; while none is perfect, most are useful. Because of the special ability of cantharidin to disorganize epidermal cells, we decided to explore its use as a chemotherapeutic agent in warts. Materials and Methods Cantharides is dried, powdered
W L, EPSTEIN, A M, KLIGMAN
openaire   +2 more sources

Covalent Binding of Reactive Anhydride of Cantharidin to Biological Amines

Drug Metabolism And Disposition
Cantharidin is a terpenoid from coleoptera beetles. Cantharidin has been used to treat molluscum contagiosum and some types of tumors. Cantharidin is highly toxic, and cantharidin poisoning and fatal cases have been reported worldwide.
Yaya Fan, Lin Chen, Qiuyi Jing, Xiaoli Li, H. Pan, Chao Fang, Jianyong Zhang, Fuguo Shi   +7 more
semanticscholar   +1 more source

Cantharidin treatment inhibits hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner.

Pharmacological Research, 2020
Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. The tyrosine kinase receptor EphB4 promotes oncogenesis and tumor development and progression.
Man Zhu, Xianpeng Shi, Zhengyan Gong, Qi Su, Runze Yu, Bo Wang, Tianfeng Yang, Bingling Dai, Ying-zhuan Zhan, Dongdong Zhang, Yanmin Zhang   +10 more
semanticscholar   +1 more source

Cantharidin

2000
Abstract Cantharidin, the anhydride of cantharidic acid, is derived from the dried and powdered blister beetle, Cantharis vesicatoria (Spanish fly). It is used as an active ingredient of wart-removing compounds. Irritation of the membranes of the genitourinary tracts (priapism in men, pelvic congestion in women) account for its ...
openaire   +1 more source