Results 61 to 70 of about 4,608 (205)

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 6, June 2026.
To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Comparative genomics provides insights into molecular adaptation to hypermetamorphosis and cantharidin metabolism in blister beetles (Coleoptera: Meloidae).

Integrative Zoology
Blister beetles (Coleoptera: Meloidae) are currently subdivided into three subfamilies: Eleticinae (a basal group), Nemognathinae, and Meloinae. These are all characterized by the endogenous production of the defensive terpene cantharidin (CA), whereas ...
A. Riccieri, Lucrezia Spagoni, Ming Li, P. Franchini, M. N. Rossi, Emiliano Fratini, M. Cervelli, M. Bologna, Emiliano Mancini   +8 more
semanticscholar   +1 more source

Cantharidin Inhibits Proliferation of Liver Cancer by Inducing DNA Damage via KDM4A-Dependent Histone H3K36 Demethylation

Evidence-Based Complementary and Alternative Medicine, 2022
Objective To investigate the effect of cantharidin on DNA damage in hepatocellular carcinoma cells and its possible mechanism. Methods Cell proliferation assay and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were ...
Chao Wei, Xiangui Deng, Shudi Gao, Xuemei Wan, Jing Chen   +4 more
semanticscholar   +1 more source

Diterpenoid Diversity across Land Plants

Helvetica Chimica Acta, Volume 109, Issue 4, April 2026.
Here we bridge the knowledge of diterpene chemical diversity, biosynthesis, and evolution from nonvascular mosses and liverworts to that known from vascular plants. ABSTRACT The diverse array of diterpenoid natural products stems from the ease of manipulating the promiscuity of diterpene cyclases.
Anita Berg, Chad K. Papenfuhs, Amy E. Fraley   +2 more
wiley   +1 more source

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, Volume 7, Issue 2, March 2026.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Glycyrrhetinic acid-modified redox-sensitive polymeric mixed micelles for tumor-specific intracellular delivery of cantharidin

RSC Advances
Cantharidin (CTD) has been widely used to treat hepatocellular carcinoma (HCC) in clinical practice. However, the current CTD preparations may induce hepatic and renal damage due to their non-specific distribution.
Yu Hu, Tian Lan, Ji Li, Lingjun Li, Jizheng Song   +4 more
semanticscholar   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

The Mechanism of Cantharidin Acantholysis

Journal of Investigative Dermatology, 1962
In an earlier paper (1), we reviewed the literature concerning eantharidin aeantholysis and commented on the theories thus far proposed to explain its production. New data were presented, and it was concluded that no adequate biochemical explanation currently exists.
Weakley, David R., Einbinder, Julia M.
openaire   +2 more sources

Male‐Biased Adult Mortality in the Great Bustard Is Consistent With High Reproductive Costs and Aggravated by Anthropogenic Impact

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Annual survival of great bustards (Otis tarda) was lower in males than in females, with minimum values just after the mating and incubation period, respectively, a pattern that is consistent with the reproductive cost hypothesis. Survival was lower in Madrid, a highly anthropized region (males: 0.874, females: 0.931), than in Villafáfila, where good ...
Juan C. Alonso, Beatriz Martín, Carlos Palacín, Carlos A. Martín, Javier A. Alonso   +4 more
wiley   +1 more source