Results 71 to 80 of about 2,630 (258)

SALDOS MONETARIOS REALES Y APORTES DESDE LA ECONOMÍA CONDUCTUAL Y EL CAOS: CASO VENEZUELA

Semestre Económico
Estudiar los determinantes de la inflación es relevante en economías inflacionarias para dilucidar con mayor precisión los instrumentos de política macroeconómica a fin de combatirla. En este trabajo, en primer lugar, se analizan los determinantes de la
José Contreras, Karelys Medina
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Reflexões sobre as possibilidades e as limitações histórico-sociais para a reprodução do capitalismo: um estudo sobre o "colapso da modernização"

Mediações: Revista de Ciências Sociais, 1997
Este trabalho se constitui em uma reflexão sobre a análise de Robert Kurz, no que tange às potencialidades e limitações histórico-sociais da expansão do capitalismo, e de suas contradições internas.
Marcelo Caetano de Cernev Rosa
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Teorías sobre la conducción operacional: Las gramáticas bélicas, desde Clausewitz a la actualidad

Tiempo Devorado, 2016
La práctica totalidad del pensamiento militar contemporáneo coincide en el carácter sistémico y complejo de la guerra. Las divergencias surgen a la hora de interpretar esa complejidad que, a su vez, constituye el cauce para concepciones diversas, e ...
Pedro Valdés Guía
doaj  

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

No linealidad, complejidad y sistemas sociales

Revista de Antropología y Sociología Virajes, 2008
El artículo inicia presentando un panorama acerca de los intentos de elaborar modelos de la realidad, que van desde la visión lineal clásica de las ciencias naturales hasta concepciones que aceptan la existencia del  caos y de la impredecibilidad. Luego
Graciela Chaparro Guevara
doaj  

Determinism, chaos, self-organization and entropy

Anais da Academia Brasileira de Ciências, 2016
We discuss two changes of paradigms that occurred in science along the XXth century: the end of the mechanist determinism, and the end of the apparent incompatibility between biology, where emergence of order is law, and physics, postulating a ...
JOSÉ PONTES
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Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source