Results 91 to 100 of about 2,630 (258)
Enfermagem Brasil, 2014 Existem palavras na língua portuguesa que muitas vezes nos confundem quanto ao seu significado e correta aplicação. Uma delas é a palavra "sofisticado". Parece senso comum que é muito bom ser sofisticado, ter um gosto sofisticado, usar roupas sofisticadas, ir a um restaurante sofisticado, ler livros sofisticados, e por aí vai.
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Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
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Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
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Additive Manufacturing of High‐Performance Polymers for Extreme Environments
Advanced Science, EarlyView.Additive manufacturing of high‐performance polymers for extreme environments is critically reviewed through an integrated chemistry‐processing‐structure‐property‐qualification framework. The review compares fused filament fabrication, selective laser sintering, and direct ink writing, linking rheology and thermal history to crystallization, defect ...
Md Tofazzal Hossain +7 more
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Advanced Science, EarlyView.Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun +18 more
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Advanced Science, EarlyView.The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang +7 more
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Veredes, Arquitectura y Divulgación, 2020 La ciudad es un sistema complejo de organización y comunicación. La correcta lectura de su mecánica evolutiva, requiere entender necesariamente sus particulares estructuras de orden, las que naturalmente subvierten las ideas tradicionales que tenemos al ...
Francisco Javier Parada Pino
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Cell ReportsWe discuss with Bin Cao his work on HAVCR1 as a receptor for Zika virus in placental trophoblasts and its role in vertical transmission.
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Reducing Ion Transport Friction by Mitigated Diluent‐Solvent Interaction for Sodium–Sulfur Battery
Advanced Science, EarlyView.A local high‐concentration electrolyte to balance the ionic conductivity and interfacial stability is developed through replacing the high solvating DME with the moderate solvating diethyl ether to mitigate the diluent‐solvent interaction and reduce the local dynamic friction for Na+ transport, while maintaining the anion‐rich solvation clusters and ...
Sihang Xia +9 more
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Revista de la Facultad de Medicina, 1994 Caos en el caos / La lidocaína bajo sospecha / En la era del trasplante celular ...
Facultad de Medicina Revista
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