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Studies of cap-independent mRNA translation in Drosophila melanogaster
, 2004 Control of protein synthesis is a key step in the regulation of gene expression during apoptosis and the heat shock response. Under such conditions, cap-dependent translation is impaired and Internal Ribosome Entry Site (IRES)-dependent translation plays a major role in mammalian cells.
Vazquez-Pianzola, P.
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Virology, 1999 A 3′ translation enhancer (3′TE) sequence that facilitates cap-independent translation is located near the 3′ end of barley yellow dwarf luteovirus RNA.
W Allen Miller
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Cap-independent translation initiation of the unspliced RNA of retroviruses
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020Retroviruses are a unique family of RNA viruses that utilize a virally encoded reverse transcriptase (RT) to replicate their genomic RNA (gRNA) through a proviral DNA intermediate. The provirus is permanently integrated into the host cell chromosome and is expressed by the host cell transcription, RNA processing, and translation machinery.
Aldo, Barrera +3 more
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Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
Science, 2007Cellular internal ribosome entry sites (IRESs) are untranslated segments of mRNA transcripts thought to initiate protein synthesis in response to environmental stresses that prevent canonical 5′ cap–dependent translation. Although numerous cellular mRNAs are proposed to have IRESs, none has a demonstrated physiological function or molecular mechanism ...
Wendy V, Gilbert +3 more
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Cap-Independent Translation of Heat Shock Messenger RNAs
1995An early concept in the development of the field of translational control was that mRNAs differ in their intrinsic efficiencies of binding to ribosomes (Lodish 1976). Dozens of examples of mRNAs have now been described for which differences in efficiency of translation are attributed to differences in cap accessibility, secondary structure, sequence ...
R E, Rhoads, B J, Lamphear
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1995
List of Contents.- Cap-Dependent and Cap-Independent Translation: Operational Distinctions and Mechanistic Interpretations.- Translation of Encephalomyocarditis Virus RNA by Internal Ribosomal Entry.- Anatomy of the Poliovirus Internal Ribosome Entry Site.- The Role of the La Autoantigen in Internal Initiation.- Structure and Function of the Hepatitis ...
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List of Contents.- Cap-Dependent and Cap-Independent Translation: Operational Distinctions and Mechanistic Interpretations.- Translation of Encephalomyocarditis Virus RNA by Internal Ribosomal Entry.- Anatomy of the Poliovirus Internal Ribosome Entry Site.- The Role of the La Autoantigen in Internal Initiation.- Structure and Function of the Hepatitis ...
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Cap-Independent Translation in Adenovirus Infected Cells
1995Adenoviruses (Ads) are DNA viruses that infect humans, animals and birds, with different serotypes displaying different tissue tropisms (Beladi 1972). Ad was originally isolated because infection results in cytopathic effects and alterations in basic cellular metabolism. The Ad genome is temporally organized into early and late transcription units that
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Cap-dependent and cap-independent translation in eukaryotic systems
Gene, 2004Unlike bacterial protein synthesis, eukaryotic protein synthesis has several mechanisms to initiate translation including cap-dependent initiation, re-initiation and internal initiation. While there is extensive biochemical characterization of the multiple steps in cap-dependent initiation, most of the information on the other two mechanisms is derived
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1995
Before RNA transcription is completed by RNA polymerase II, the 5’ ends of eukaryotic mRNA molecules are modified. Mediated by a series of enzymatic reactions, a 7-methyl GpppN (in which N can be any nucleotide) “cap” structure is added to the 5’ end of each primary transcript (Banerjee 1980; Shatkin 1976).
N, Iizuka +4 more
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Before RNA transcription is completed by RNA polymerase II, the 5’ ends of eukaryotic mRNA molecules are modified. Mediated by a series of enzymatic reactions, a 7-methyl GpppN (in which N can be any nucleotide) “cap” structure is added to the 5’ end of each primary transcript (Banerjee 1980; Shatkin 1976).
N, Iizuka +4 more
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An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation
Nature Neuroscience, 2003The rate of translation of egg-laying hormone (ELH) in Aplysia californica bag cell neurons rises after an afterdischarge (AD), the physiological trigger for egg-laying1. We found that the 5′ untranslated region (5′ UTR) of ELH possessed an internal ribosomal entry site (IRES), and that an AD was accompanied by a switch to cap-independent, IRES ...
John R, Dyer +5 more
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