Captivating Perplexities of Spinareovirinae 5′ RNA Caps [PDF]
Viruses, 2021 RNAs with methylated cap structures are present throughout multiple domains of life. Given that cap structures play a myriad of important roles beyond translation, such as stability and immune recognition, it is not surprising that viruses have adopted ...
Justine Kniert +2 more
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Dinucleoside polyphosphates act as 5′-RNA caps in bacteria [PDF]
Nature Communications, 2020 Nicotinamide adenine dinucleotide and coenzyme A serve as a 5′-cap of prokaryotic RNA. Here the authors report that methylated and non-methylated dinucleoside polyphosphates (Np n Ns) exist as Escherichia coli RNA caps which can be cleaved by 5 ...
Oldřich Hudeček +9 more
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NADcapPro and circNC: methods for accurate profiling of NAD and non-canonical RNA caps in eukaryotes [PDF]
Communications Biology, 2023 Accurate identification of NAD-capped RNAs is essential for delineating their generation and biological function. Previous transcriptome-wide methods used to classify NAD-capped RNAs in eukaryotes contain inherent limitations that have hindered the ...
Sunny Sharma +4 more
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Influenza A virus preferentially snatches noncoding RNA caps [PDF]
Rna, 2015 Influenza A virus (IAV) lacks the enzyme for adding 5' caps to its RNAs and snatches the 5' ends of host capped RNAs to prime transcription. Neither the preference of the host RNA sequences snatched nor the effect of cap-snatching on host processes is ...
Weifeng Gu, Weiwei Dai, Ping Liu
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mRNA caps accumulate in stress granules and are essential for their formation [PDF]
Cellular and Molecular Life SciencesStress granules (SGs) are essential cytoplasmic, membraneless organelles that form in response to cellular stress, functioning to prevent mRNA translation and protect mRNA from damage. However, the mechanism of SG formation remains largely unknown. Here,
Mingxin Guo +7 more
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Pan-cancer multi-omics characterization of calcyphosine and its revealed links to the immune microenvironment and regulatory networks in endometrial carcinoma [PDF]
Frontiers in ImmunologyObjectiveThe calcium-dependent activator protein for secretion (CAPS) has emerged as a protein of interest in tumor biology; however, its functional significance in endometrial carcinoma (EC) remains largely unexplored.MethodsWe performed an integrative ...
Xi Chen +7 more
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mSystems, 2023 Both prokaryotic and eukaryotic RNAs can be 5′-capped by the metabolite nicotinamide adenine dinucleotide (NAD). Nudix hydrolases, such as bacterial NudC, specifically remove NAD-caps; however, the molecular and cellular functions of these ...
Milda Mickutė +10 more
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CompasSeq: epitranscriptome-wide percentage assessment of metabolite-capped RNA at the transcript resolution [PDF]
Nature CommunicationsNucleotide-containing metabolites, e.g., NAD, can serve as noncanonical initiating nucleotides (NCIN) during transcription, yielding NCIN-capped RNAs (NCIN-RNAs).
Yuanbo Liu +6 more
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Applications of Phosphate Modification and Labeling to Study (m)RNA Caps [PDF]
Topics in Current Chemistry, 2017 Marcin Warminski +2 more
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Interaction Network of Porcine Circovirus Type 3 and 4 Capsids with Host Proteins
Viruses, 2022 An extensive understanding of the interactions between host cellular and viral proteins provides clues for studying novel antiviral strategies. Porcine circovirus type 3 (PCV3) and type 4 (PCV4) have recently been identified as viruses that can ...
Jianwei Zhou +8 more
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