Results 31 to 40 of about 29,994 (285)
Helix Capping in RNA Structure
PLoS ONE, 2014 Helices are an essential element in defining the three-dimensional architecture of structured RNAs. While internal basepairs in a canonical helix stack on both sides, the ends of the helix stack on only one side and are exposed to the loop side, thus susceptible to fraying unless they are protected.
Lee, Jung C., Gutell, Robin R.
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Extensive 5′-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast
Nature Communications, 2020 NAD (nicotinamide adenine dinucleotide) acts as a non-canonical RNA cap structure in bacteria and eukaryotes. Here the authors demonstrate the whole landscape of budding yeast NAD-RNAs which are subject to diverse surveillance pathways, suggesting that ...
Yaqing Zhang +9 more
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Cell Death Discovery, 2022 7-methylguanosine (m7G) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various RNA metabolisms.
Haiyun Xie +13 more
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RNA capping: progress and prospects [PDF]
RNA, 2015 The 5′ m7GpppN cap, co-discovered by Shatkin, Furuichi, and Moss in 1975, is the signature feature of eukaryal cellular and viral messenger RNA that confers mRNA stability and efficient translation. Cap formation entails three sequential enzymatic modifications targeted to nascent pre-mRNAs synthesized by cellular or viral RNA polymerases. First, the 5′
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RNA methyltransferases involved in 5′ cap biosynthesis [PDF]
RNA Biology, 2014 In eukaryotes and viruses that infect them, the 5' end of mRNA molecules, and also many other functionally important RNAs, are modified to form a so-called cap structure that is important for interactions of these RNAs with many nuclear and cytoplasmic proteins.
Byszewska M +3 more
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Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
Proceedings of the National Academy of Sciences, 2022 Alphaviruses are emerging positive-stranded RNA viruses which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm. The nonstructural protein 1 (nsP1) is responsible for viral RNA capping and gates the replication organelles by assembling into monotopic membrane-associated dodecameric pores ...
Jones, Rhian +5 more
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Metabolites, 2022 Salt-induced renal metabolism dysfunction is an important mechanism of salt-sensitive hypertension. Given that the gut-liver axis is the first hit of a high-salt diet (HSD), we aimed to identify the extra-renal mechanism from hepatic metabolism and gut ...
Ya-nan Ou-Yang +5 more
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Sequestering the 5′‐cap for viral RNA packaging
BioEssays, 2022 AbstractMany viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre ...
Pengfei Ding, Michael F. Summers
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A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]
, 2014 Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Winter, Ulrike +4 more
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The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme [PDF]
Nucleic Acids Research, 2021 Abstract SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant morbidity, mortality and economic strain. SARS-CoV-2 can cause severe respiratory disease and death in humans, highlighting the need for effective antiviral therapies.
Walker, AP +5 more
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