Results 21 to 30 of about 29,994 (285)
Deciphering the RNA capping process in bacteria [PDF]
Proceedings of the National Academy of Sciences, 2020 RNA capping in eukaryotes has been studied since the 1970s, starting with the discovery of 5′ 7-methylguanylate caps in the Shatkin laboratory (1). That capping mechanism involves a pause during transcription elongation that allows the recruitment of specialized capping enzymes to modify the 5′ end of the nascent RNA.
Jonathan, Jagodnik, Richard L, Gourse
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Biomedicines, 2022 This study aims to investigate whether tissue oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, plays an active role in age-dependent susceptibility to hypertension in response to nitric oxide (NO ...
Yung-Mei Chao +2 more
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The expanding field of non-canonical RNA capping: new enzymes and mechanisms
Royal Society Open Science, 2021 Recent years witnessed the discovery of ubiquitous and diverse 5′-end RNA cap-like modifications in prokaryotes as well as in eukaryotes. These non-canonical caps include metabolic cofactors, such as NAD+/NADH, FAD, cell wall precursors UDP-GlcNAc ...
Jana Wiedermannová +2 more
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Frontiers in Molecular Biosciences, 2022 Many eukaryotic and some bacterial RNAs are modified at the 5′ end by the addition of cap structures. In addition to the classic 7-methylguanosine 5′ cap in eukaryotic mRNA, several non-canonical caps have recently been identified, including NAD-linked ...
Anaïs Depaix +6 more
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STAR Protocols, 2020 Summary: Nucleoside-containing metabolites such as the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD+ and NADH), 3′-desphospho-coenzyme A (dpCoA), and flavin adenine dinucleotide (FAD) can be incorporated as RNA 5′ end caps by ...
Irina O. Vvedenskaya, Bryce E. Nickels
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Biological roles of DExH RNA helicase, RHAU [PDF]
, 2007 In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
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The effect of ppGpp and DksA on NAD+ capped RNA species
, 2023 Bird, Jeremy. G.5´ end ribonucleic acid caps play an important role in both regulation of gene expression and half-life of RNAs. Canonically, eukaryotes utilize the evolutionarily conserved methyl-7-guanosine (m7G) cap for mRNA nuclear export and to ...
George, Raymond Albert, IV
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Viruses, 2020 The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2′-O-methyltransferase (2′-O-MTase) capping machinery to camouflage its RNA from innate immune recognition.
José Antonio Encinar +1 more
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BMC Genomics, 2022 Background The selection of tissue culture–derived somaclonal variants of Giant Cavendish banana (Musa spp., Cavendish sub-group AAA) by the Taiwan Banana Research Institute (TBRI) has resulted in several cultivars resistant to Fusarium oxysporum f.
Bo-Han Hou +6 more
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Pharmaceutics, 2023 The development of effective anti-cancer therapeutics remains one of the current pharmaceutical challenges. The joint delivery of chemotherapeutic agents and biopharmaceuticals is a cutting-edge approach to creating therapeutic agents of enhanced ...
Apollinariia Dzhuzha +7 more
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