Results 1 to 10 of about 2,703,843 (291)
Click Chemistry in Polymersome Technology
PharmaceuticalsPolymersomes, self-assembled nanoparticles composed of amphiphilic block copolymers, have emerged as promising versatile nanovesicles with various applications, such as drug delivery, medical imaging, and diagnostics.
Nuno M. Saraiva +3 more
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Bio-click chemistry: a bridge between biocatalysis and click chemistry
RSC Advances, 2022 This review summarizes chemo/biocatalytic syntheses that combine the highly efficient click chemistry reactions with the advantages of biocatalysis. The concept of bio-click chemistry and its implications are introduced in this review.
Diego F. Rodríguez +5 more
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Advancements and applications of click chemistry in protein labeling and bioconjugation [PDF]
RSC AdvancesClick chemistry has emerged as a versatile and efficient chemical strategy for constructing complex molecules under mild conditions. Its core reaction is copper(i)-catalyzed azide–alkyne cycloaddition (CuAAC), which provides high yields ...
Usman Nazeer, Guoting Qin, Chengzhi Cai
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AutoClickChem: click chemistry in silico. [PDF]
PLoS Computational Biology, 2012 Academic researchers and many in industry often lack the financial resources available to scientists working in "big pharma." High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges,
Jacob D Durrant, J Andrew McCammon
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Click chemistry-driven tumor theranostics: recent advances, challenges, and future perspectives [PDF]
Cancer Biology & MedicineTumor theranostics, which integrates accurate diagnosis and precise therapy, has emerged as a pivotal approach in modern oncology for improving treatment efficacy and reducing off-target toxicity.
Dayong Hou +4 more
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Click Chemistry-Based Hydrogels for Tissue Engineering [PDF]
GelsClick chemistry has become a powerful and flexible approach for designing hydrogels used in tissue engineering thanks to its high specificity, fast reaction rates, and compatibility with biological systems.
Soheil Sojdeh +4 more
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Click Reactions in Medicinal Chemistry
Pharmaceuticals, 2023 Two decades after K [...]
Damien Bosc
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Click chemistry as a promising protocol for fluorogenic reactions [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 The Nobel prize in chemistry has been awarded to the click chemistry approach in 2022 due to its significant impact on nearly all fields of chemical science.
Heba Aref +4 more
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Click Chemistry with Cyclopentadiene
Chemical Reviews, 2021 Cyclopentadiene is one of the most reactive dienes in normal electron-demand Diels-Alder reactions. The high reactivities and yields of cyclopentadiene cycloadditions make them ideal as click reactions. In this review, we discuss the history of the cyclopentadiene cycloaddition as well as applications of cyclopentadiene click reactions. Our emphasis is
Brian J. Levandowski, Ronald T. Raines
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Click chemistry and drug delivery: A bird's-eye view
Acta Pharmaceutica Sinica B, 2023 Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task.
Shameer M. Kondengadan +5 more
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