Results 1 to 10 of about 1,698 (209)
AutoClickChem: click chemistry in silico. [PDF]
PLoS Computational Biology, 2012 Academic researchers and many in industry often lack the financial resources available to scientists working in "big pharma." High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges,
Jacob D Durrant, J Andrew McCammon
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Click Reactions in Medicinal Chemistry
Pharmaceuticals, 2023 Two decades after K [...]
Damien Bosc
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Click Chemistry in Polymersome Technology
PharmaceuticalsPolymersomes, self-assembled nanoparticles composed of amphiphilic block copolymers, have emerged as promising versatile nanovesicles with various applications, such as drug delivery, medical imaging, and diagnostics.
Nuno M. Saraiva +3 more
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Click chemistry as a promising protocol for fluorogenic reactions [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 The Nobel prize in chemistry has been awarded to the click chemistry approach in 2022 due to its significant impact on nearly all fields of chemical science.
Heba Aref +4 more
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Click Chemistry with Cyclopentadiene
Chemical Reviews, 2021 Cyclopentadiene is one of the most reactive dienes in normal electron-demand Diels-Alder reactions. The high reactivities and yields of cyclopentadiene cycloadditions make them ideal as click reactions. In this review, we discuss the history of the cyclopentadiene cycloaddition as well as applications of cyclopentadiene click reactions. Our emphasis is
Brian J. Levandowski, Ronald T. Raines
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Click chemistry and drug delivery: A bird's-eye view
Acta Pharmaceutica Sinica B, 2023 Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task.
Shameer M. Kondengadan +5 more
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Bio-click chemistry: a bridge between biocatalysis and click chemistry
RSC Advances, 2022 This review summarizes chemo/biocatalytic syntheses that combine the highly efficient click chemistry reactions with the advantages of biocatalysis. The concept of bio-click chemistry and its implications are introduced in this review.
Diego F. Rodríguez +5 more
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Click chemistry with DNA [PDF]
Chemical Society Reviews, 2010 The advent of click chemistry has led to an influx of new ideas in the nucleic acids field. The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is the method of choice for DNA click chemistry due to its remarkable efficiency. It has been used to label oligonucleotides with fluorescent dyes, sugars, peptides and other reporter groups, to ...
El-Sagheer, Afaf H., Brown, Tom
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Biocompatible nanoreactors of catalase and nanozymes for anticancer therapeutics
Nano Select, 2021 Significant progress has laid the groundwork in understanding the fundamental role of catalase enzyme and catalase‐like nanozymes, notably with the emergence of nano‐bioreactors which are promoting nanomaterials‐based antitumor therapeutic strategies ...
Tanya Munjal, Saikat Dutta
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Molecules, 2021 The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules.
Daniela Perrone +3 more
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