Results 11 to 20 of about 3,191,477 (292)

AutoClickChem: click chemistry in silico. [PDF]

PLoS Computational Biology, 2012
Academic researchers and many in industry often lack the financial resources available to scientists working in "big pharma." High costs include those associated with high-throughput screening and chemical synthesis. In order to address these challenges,
Jacob D Durrant, J Andrew McCammon
doaj   +4 more sources

The evolution of click chemistry: from classical reactions to next-generation platforms [PDF]

RSC Advances
Click chemistry has transformed modern synthetic chemistry by providing efficient, selective, and modular strategies for constructing complex molecular structures.
Seyed Mohammad Mahdi Dadfar, Seyed Mohammadali Dadfar   +1 more
doaj   +2 more sources

Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates

Molecules, 2013
Activity-based protein profiling uses chemical probes that covalently attach to active enzyme targets. Probes with conventional tags have disadvantages, such as limited cell permeability or steric hindrance around the reactive group.
Yinliang Yang, Xiaomeng Yang, Steven H. L. Verhelst   +2 more
doaj   +2 more sources

Click chemistry-driven tumor theranostics: recent advances, challenges, and future perspectives [PDF]

Cancer Biology & Medicine
Tumor theranostics, which integrates accurate diagnosis and precise therapy, has emerged as a pivotal approach in modern oncology for improving treatment efficacy and reducing off-target toxicity.
Dayong Hou, Xiangpeng Li, Niyuan Zhang, Xingyan Fu, Hao Wang   +4 more
doaj   +2 more sources

Click Chemistry in Human Cancer Research [PDF]

Zhongliu Fangzhi Yanjiu
As one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj   +3 more sources

Applications of Click Chemistry in Radiopharmaceutical Development [PDF]

CHIMIA, 2010
Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of chemistry, including material sciences and drug discovery.
Joseph C. Walsh, Hartmuth C. Kolb
doaj   +2 more sources

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

Molecules, 2013
Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
doaj   +2 more sources

Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry

Pharmaceuticals
Background: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach.
Samantha Leier, Frank Wuest
doaj   +2 more sources

Click Chemistry-Based Hydrogels for Tissue Engineering [PDF]

Gels
Click chemistry has become a powerful and flexible approach for designing hydrogels used in tissue engineering thanks to its high specificity, fast reaction rates, and compatibility with biological systems.
Soheil Sojdeh, Amirhosein Panjipour, Amal Yaghmour, Zohreh Arabpour, Ali R. Djalilian   +4 more
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Click Reactions in Medicinal Chemistry

Pharmaceuticals, 2023
Two decades after K [...]
Damien Bosc
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