Results 1 to 10 of about 11,629 (239)
Bioorthogonal chemistry. [PDF]
Nat Rev Methods Primers, 2021 Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups. Rooted in the principles of physical organic chemistry, bioorthogonal reactions are intrinsically selective transformations not commonly found in ...
Scinto SL +13 more
europepmc +9 more sources
Tetrazine bioorthogonal chemistry derived in vivo imaging [PDF]
Frontiers in Molecular Biosciences, 2022 Bioorthogonal chemistry represents plenty of highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations without unexpected side reactions towards miscellaneous endogenous functional groups.
Gaoxiang Zhao +9 more
doaj +4 more sources
The Future of Bioorthogonal Chemistry [PDF]
ACS Central Science, 2018 Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous reactions that can be predictably performed in a biological setting. Depending on the requirements of the intended application, one or more reactions from the available toolkit can be readily deployed ...
Neal K. Devaraj
doaj +5 more sources
Bioorthogonal Chemistry in Cellular Organelles. [PDF]
Top Curr Chem (Cham), 2023 AbstractWhile bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular
Šlachtová V +3 more
europepmc +4 more sources
Bioorthogonal chemistry of polyoxometalates - challenges and prospects. [PDF]
Chem Sci, 2023 Bioorthogonal chemistry enabled scientists to carry out controlled chemical processes in high yields in vivo while minimizing hazardous effects. Its extension to the field of polyoxometalates (POMs) could open up new possibilities and new applications in molecular electronics, sensing and catalysis, including inside living cells.
Petrovskii SK, Grachova EV, Monakhov KY.
europepmc +3 more sources
Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry [PDF]
Signal Transduction and Targeted Therapy, 2022 Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic engineering, bioorthogonal groups can be tagged onto cell membranes, which selectively attach to cargos with ...
Wenzhe Yi +10 more
doaj +2 more sources
Bioorthogonal chemistry: Bridging chemistry, biology, and medicine. [PDF]
Chem, 2023 As chemical biologists sought methods to modify and study biomolecules in their native environments, the need for bioorthogonal chemical reactions emerged. These fast and selective reactions between otherwise inert, abiotic functional groups have enabled exploration of some of the most intriguing and challenging questions in chemical biology.
Hartung KM, Sletten EM.
europepmc +3 more sources
Not So Bioorthogonal Chemistry. [PDF]
J Am Chem SocThe advent of bioorthogonal chemistry has transformed scientific research, offering a powerful tool for selective and noninvasive labeling of (bio)molecules within complex biological environments. This innovative approach has facilitated the study of intricate cellular processes, protein dynamics, and interactions.
Schauenburg D, Weil T.
europepmc +5 more sources
Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance [PDF]
Materials Today BioCervical cancer remains a significant health burden among women worldwide, with drug resistance posing a major obstacle to effective treatment strategies.
Xue Yang, Yang Gu
doaj +2 more sources
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers [PDF]
Pharmaceutics, 2022 Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity
Alice D’Onofrio +9 more
doaj +2 more sources