Nature Reviews Methods Primers, 2021 Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups.
Robert Hincapié +2 more
exaly +10 more sources
Tetrazine bioorthogonal chemistry derived in vivo imaging [PDF]
Frontiers in Molecular Biosciences, 2022 Bioorthogonal chemistry represents plenty of highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations without unexpected side reactions towards miscellaneous endogenous functional groups.
Gaoxiang Zhao +9 more
doaj +4 more sources
Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
Molecules, 2013 Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
doaj +4 more sources
Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance [PDF]
Materials Today BioCervical cancer remains a significant health burden among women worldwide, with drug resistance posing a major obstacle to effective treatment strategies.
Xue Yang, Yang Gu
doaj +3 more sources
Toward Realization of Bioorthogonal Chemistry in the Clinic [PDF]
Topics in Current ChemistryAbstract In the last decade, the use of bioorthogonal chemistry toward medical applications has increased tremendously. Besides being useful for the production of pharmaceuticals, the efficient, nontoxic reactions open possibilities for the development of therapies that rely on in vivo chemistry between two bioorthogonal components ...
Marc S Robillard +2 more
exaly +6 more sources
Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry [PDF]
Signal Transduction and Targeted Therapy, 2022 Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic engineering, bioorthogonal groups can be tagged onto cell membranes, which selectively attach to cargos with ...
Wenzhe Yi +10 more
doaj +2 more sources
Red light-responsive bioorthogonal chemistry enabled on-demand prodrug activation for cancer therapy [PDF]
Acta Pharmaceutica Sinica BLight-driven chemistry has revolutionized modern medicine, enabling precise disease detection and on-demand therapeutic interventions with high spatiotemporal accuracy. However, despite tremendous advances in bioorthogonal reactions, photoclick chemistry-
Hanzeng Cheng +15 more
doaj +2 more sources
Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines [PDF]
Nature CommunicationsBioorthogonal chemistry has become a robust toolbox with growing applications in biology and medicine. To meet diverse needs in research, new types of on-demand bioorthogonal reactions capable of responding to biological triggers or exogenous stimuli are
Dongqing Ming +9 more
doaj +2 more sources
The evolution of click chemistry: from classical reactions to next-generation platforms [PDF]
RSC AdvancesClick chemistry has transformed modern synthetic chemistry by providing efficient, selective, and modular strategies for constructing complex molecular structures.
Seyed Mohammad Mahdi Dadfar +1 more
doaj +2 more sources
Programmable nanomedicine via bioorthogonal molecular engineering [PDF]
Nano ConvergenceBioorthogonal chemistry provides a versatile strategy for programming nanomedicines beyond static carrier design. It enables post-synthetic installation of functional modules on nanoparticle surfaces, spatiotemporal control of payload activation and ...
Sunwoo Im, Seyoung Koo, Jong Seung Kim
doaj +2 more sources