Bioorthogonal chemistry: Bridging chemistry, biology, and medicine. [PDF]
Chem, 2023 As chemical biologists sought methods to modify and study biomolecules in their native environments, the need for bioorthogonal chemical reactions emerged. These fast and selective reactions between otherwise inert, abiotic functional groups have enabled exploration of some of the most intriguing and challenging questions in chemical biology.
Hartung KM, Sletten EM.
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Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications. [PDF]
Nanoscale Adv, 2021 Bioorthogonal chemistry comprises chemical reactions that can take place inside complex biological environments, providing outstanding tools for the investigation and elucidation of biological processes.
Idiago-López J +3 more
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Bioorthogonal Chemistry and Its Applications [PDF]
Bioconjugate Chemistry, 2021 Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this review, we summarize the most common reactions used in bioorthogonal methods, their relative advantages and disadvantages, and their frequency of occurrence in the published literature.
Robert E. Bird +3 more
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Azide-based bioorthogonal chemistry: Reactions and its advances in cellular and biomolecular imaging. [PDF]
Biophys Rev (Melville), 2021 Since the term “bioorthogonal” was first demonstrated in 2003, new tools for bioorthogonal chemistry have been rapidly developed. Bioorthogonal chemistry has now been widely utilized for applications in imaging various biomolecules, such as proteins ...
Alamudi SH, Liu X, Chang YT.
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The 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry. [PDF]
Anal Bioanal Chem, 2023 The 2022 Nobel Prize in Chemistry recognized the development of biorthogonal chemical ligation reactions known as click chemistry in biomedicine. This concept has catalyzed significant progress in sensing and diagnosis, chemical biology, materials chemistry, and drug discovery and delivery.
Zaia J.
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Metabolic Engineering Optimizes Bioorthogonal Glycan Labeling in Living Cells [PDF]
, 2021 Metabolic oligosaccharide engineering (MOE) has fundamentally contributed to our understanding of protein glycosylation. Efficient MOE reagents are activated into nucleotide-sugars by cellular biosynthetic machineries, introduced into glycoproteins and ...
Junwon, Choi +13 more
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Thiomethyltetrazines are Reversible Covalent Cysteine Warheads whose Dynamic Behavior can be "Switched off” via Bioorthogonal Chemistry Inside Live Cells [PDF]
, 2023 Electrophilic small molecules that can reversibly modify proteins are of growing interest in drug discovery. However, the ability to study reversible covalent probes in live cells can be limited by their reversible reactivity after cell lysis and in ...
Yingrong, Xu +4 more
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Pharmaceutics, 2023 The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni +9 more
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Azide click chemistry on magnetotactic bacteria: A versatile technique to attach a cargo
Materials Today Bio, 2023 Adding biomolecules to living organisms and cells is the basis for creating living materials or biohybrids for robotic systems. Bioorthogonal chemistry allows covalently modifying biomolecules with functional groups not natively present under biological ...
Paul Eduardo David Soto Rodriguez +3 more
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