Results 21 to 30 of about 11,629 (239)

Metabolic glycoengineering – exploring glycosylation with bioorthogonal chemistry

Chemical Society Reviews, 2023
Metabolic glycoengineering in combination with bioorthogonal chemistry provides a means to study and exploit the biological functions of glycans.
Markus Kufleitner, Lisa Maria Haiber, Valentin Wittmann   +2 more
openaire   +3 more sources

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs

Molecules, 2020
Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang, Chang Zhang, Haoxing Wu, Ping Feng   +3 more
doaj   +1 more source

Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. [PDF]

, 2015
Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions.
Houk, KN, Liang, Yong, Murphy, Jennifer M, Narayanam, Maruthi Kumar   +3 more
core   +1 more source

Minimal genetically encoded tags for fluorescent protein labeling in living neurons

Nature Communications, 2022
Site-specific labelling of proteins can be performed with unnatural amino acids combined with bioorthogonal click chemistry. Here the authors establish this in living neurons, using neurofilament light chain; they show combination with CRISPR/Cas9 ...
Aleksandra Arsić, Cathleen Hagemann, Nevena Stajković, Timm Schubert, Ivana Nikić-Spiegel   +4 more
doaj   +1 more source

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Frontiers in Chemistry, 2021
Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke, Birthe Meineke, Johannes Heimgärtner, Johannes Heimgärtner, Alexander J. Craig, Michael Landreh, Lindon W. K. Moodie, Lindon W. K. Moodie, Simon J. Elsässer, Simon J. Elsässer   +9 more
doaj   +1 more source

Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization [PDF]

, 2017
The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes.
Cao-Milán, R., Das, R., He, L.D., Rotello, V.M., Shorkey, S., Sulak, Mine, Tonga, G.Y., Uddin, I., Wang, L.-S., Zhang, X.   +9 more
core   +1 more source

Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis [PDF]

, 2011
Proteins in living cells can be made receptive to bioorthogonal chemistries through metabolic labeling with appropriately designed noncanonical amino acids (ncAAs).
Ngo, John T., Tirrell, David A.
core   +2 more sources

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking

Nature Communications, 2021
The analysis of AMPA-type glutamate receptor (AMPAR) trafficking is essential for understanding molecular mechanisms of learning and memory, but the analytical tools are currently limited.
Kento Ojima, Kazuki Shiraiwa, Kyohei Soga, Tomohiro Doura, Mikiko Takato, Kazuhiro Komatsu, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka   +8 more
doaj   +1 more source

Click Chemistry in Human Cancer Research

Zhongliu Fangzhi Yanjiu
As one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj   +2 more sources

Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry

STAR Protocols, 2023
Summary: Bioorthogonal labeling and click chemistry techniques allow the detailed examination of cellular physiology through tagging and visualizing newly synthesized proteins.
Alison Keolani Carlisle, Jürgen Götz, Liviu-Gabriel Bodea   +2 more
doaj   +1 more source