Results 11 to 20 of about 11,629 (239)
Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines [PDF]
Nature CommunicationsBioorthogonal chemistry has become a robust toolbox with growing applications in biology and medicine. To meet diverse needs in research, new types of on-demand bioorthogonal reactions capable of responding to biological triggers or exogenous stimuli are
Dongqing Ming +9 more
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Bioorthogonal chemistry: strategies and recent developments. [PDF]
Chem Commun (Camb), 2013 The use of covalent chemistry to track biomolecules in their native environment-a focus of bioorthogonal chemistry-has received considerable interest recently among chemical biologists and organic chemists alike. To facilitate wider adoption of bioorthogonal chemistry in biomedical research, a central effort in the last few years has been focused on ...
Ramil CP, Lin Q.
europepmc +4 more sources
Bioorthogonal Chemistry and Its Applications [PDF]
Bioconjugate Chemistry, 2021 Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this review, we summarize the most common reactions used in bioorthogonal methods, their relative advantages and disadvantages, and their frequency of occurrence in the published literature.
Robert E. Bird +3 more
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Designing Bioorthogonal Reactions for Biomedical Applications
Research, 2023 Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency.
Qingfei Zhang +5 more
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Pharmaceutics, 2023 The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni +9 more
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Azide click chemistry on magnetotactic bacteria: A versatile technique to attach a cargo
Materials Today Bio, 2023 Adding biomolecules to living organisms and cells is the basis for creating living materials or biohybrids for robotic systems. Bioorthogonal chemistry allows covalently modifying biomolecules with functional groups not natively present under biological ...
Paul Eduardo David Soto Rodriguez +3 more
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Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]
, 2020 An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V. +6 more
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Human T cell glycosylation and implications on immune therapy for cancer [PDF]
, 2020 Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico +3 more
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Bioorthogonal Reactions in Activity-Based Protein Profiling
Molecules, 2020 Activity-based protein profiling (ABPP) is a powerful technique to label and detect active enzyme species within cell lysates, cells, or whole animals. In the last two decades, a wide variety of applications and experimental read-out techniques have been
Steven H. L. Verhelst +2 more
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