Results 11 to 20 of about 2,778,442 (233)
Not So Bioorthogonal Chemistry. [PDF]
J Am Chem SocThe advent of bioorthogonal chemistry has transformed scientific research, offering a powerful tool for selective and noninvasive labeling of (bio)molecules within complex biological environments.
Schauenburg D, Weil T.
europepmc +7 more sources
Bioorthogonal Chemistry of Polyoxometalates – Challenges and Prospects [PDF]
Chemical Science, 2023 Bioorthogonal chemistry enabled scientists to carry out controlled chemical processes in high yields in vivo while minimizing hazardous effects. Its extension to the field of polyoxometalates (POMs) could open up new possibilities and new applications in
Stanislav K., Petrovskii +2 more
core +3 more sources
The Future of Bioorthogonal Chemistry [PDF]
ACS Central Science, 2018 Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous reactions that can be predictably performed in a biological setting. Depending on the requirements of the intended application, one or more reactions from the available toolkit can be readily deployed ...
Neal K. Devaraj
doaj +5 more sources
Bioorthogonal chemistry in bioluminescence imaging
Drug Discovery Today, 2018 Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry.
Godinat, Aurelien +8 more
core +5 more sources
Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
doaj +2 more sources
Designing Bioorthogonal Reactions for Biomedical Applications
Research, 2023 Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency.
Qingfei Zhang +5 more
doaj +2 more sources
Click Chemistry in Human Cancer Research [PDF]
Zhongliu Fangzhi YanjiuAs one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj +3 more sources
Intracellular bioorthogonal chemistry [PDF]
, 2018 Bioorthogonal reactions have a central role in medicinal therapeutics and diagnostics. Extracellularly binding substances, like antibodies, are often used as targeting agents and are coupled with a bioorthogonal reaction agent.
Sporer, Emanuel
core +2 more sources
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid [PDF]
Beilstein Journal of Organic Chemistry, 2010 Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal
Arne Homann +4 more
doaj +2 more sources
Bioorthogonal Chemistry in Cellular Organelles. [PDF]
Top Curr Chem (Cham), 2023 AbstractWhile bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular
Šlachtová V +3 more
europepmc +4 more sources