Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
Nature Communications, 2021 The analysis of AMPA-type glutamate receptor (AMPAR) trafficking is essential for understanding molecular mechanisms of learning and memory, but the analytical tools are currently limited.
Kento Ojima +8 more
doaj +1 more source
Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
Molecules, 2021 Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron ...
Sang-Kee Choi, Jonghoon Kim, Eunha Kim
doaj +1 more source
Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine [PDF]
, 2014 Bioorthogonal chemistry has become one of the main driving forces in current chemical biology, inspiring the search for novel biocompatible chemospecific reactions for the past decade.
Neil O. Carragher (1324512) +28 more
core +1 more source
Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity
eLife, 2020 Several virulence lipids populate the outer cell wall of pathogenic mycobacteria. Phthiocerol dimycocerosate (PDIM), one of the most abundant outer membrane lipids, plays important roles in both defending against host antimicrobial programs and in ...
CJ Cambier +3 more
doaj +1 more source
Cutting-edge bioorthogonal chemistry: Innovations, practical applications, and emerging trends [PDF]
Bioorthogonal chemistry has emerged as a pivotal field in molecular science, offering transformative tools for applications in drug discovery, imaging, and molecular biology.
Chetry, Anup Basnet
core +1 more source
Polymer-Based Bioorthogonal Nanocatalysts for Bacterial Biofilm Treatment [PDF]
, 2023 Bioorthogonal chemistry has emerged as a promising strategy for regulating bioprocesses through abiotic reactions. Bioorthogonal unmasking reactions mediated by transition metal catalysts (TMCs) present a powerful tool for biomedical applications due to ...
Huang, Rui
core +1 more source
Bioactive Materials, 2021 The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.
Hong Pan +14 more
doaj +1 more source
Bioorthogonal Decaging Reactions for Targeted Drug Activation
CHIMIA, 2018 Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest.
Sarah Davies +2 more
doaj +1 more source
Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics [PDF]
ChembiochemThis review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Taylor N +2 more
europepmc +2 more sources
Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy
Advanced Science, EarlyView.This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier +16 more
wiley +1 more source