Results 41 to 50 of about 11,629 (239)
Bioactive Materials, 2021 The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.
Hong Pan +14 more
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Bioorthogonal chemistry: recent progress and future directions [PDF]
Chemical Communications, 2010 The ability to use covalent chemistry to label biomolecules selectively in their native habitats has greatly enhanced our understanding of biomolecular dynamics and function beyond what is possible with genetic tools alone. To attain the exquisite selectivity that is essential in this covalent approach a "bottom-up" two-step strategy has achieved many ...
Reyna K V, Lim, Qing, Lin
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Bioorthogonal Click Chemistry-Based Synthetic Cell Glue [PDF]
Small, 2015 Artificial methods of cell adhesion can be effective in building functional cell complexes in vitro, but methods for in vivo use are currently lacking. Here, a chemical cell glue based on bioorthogonal click chemistry with high stability and robustness is introduced.
Koo, Heebeom +5 more
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Biomimetic and bioorthogonal nanozymes for biomedical applications
Nano Convergence, 2023 Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific biomolecules that can initiate or inhibit biological processes, regulating ...
Changjoon Keum +5 more
doaj +1 more source
Frontiers in Synaptic Neuroscience, 2021 Fluorescence labeling of difficult to access protein sites, e.g., in confined compartments, requires small fluorescent labels that can be covalently tethered at well-defined positions with high efficiency.
Alexander Kuhlemann +12 more
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Bioorthogonal Decaging Reactions for Targeted Drug Activation
CHIMIA, 2018 Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest.
Sarah Davies +2 more
doaj +1 more source
Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]
, 2017 Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Airaksinen, Anu +9 more
core +2 more sources
Convenient analysis of protein modification by chemical blotting with fluorogenic “click” reagents [PDF]
, 2015 Direct visualization of bioorthogonal alkyne or azide handles using fluorogenic azide–alkyne cycloaddition conducted on the surface of a blot membrane.
Ball, Zachary T. +2 more
core +1 more source
A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic
Research, 2020 In this work, we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry.
Yu Xiao +12 more
doaj +1 more source
Bioorthogonal chemistry in living organisms
Chemical Science, 2014 Bioorthogonal chemistry allows for selective and efficient modification of biomolecules in their natural environment. Several strategies have been developed over the past years that employ cellular biosynthetic pathways to incorporate the desired functionalities.
Borrmann, A. +2 more
openaire +2 more sources