Results 51 to 60 of about 2,778,442 (233)

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source

Biomimetic and bioorthogonal nanozymes for biomedical applications

Nano Convergence, 2023
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific biomolecules that can initiate or inhibit biological processes, regulating ...
Changjoon Keum, Cristina-Maria Hirschbiegel, Soham Chakraborty, Soyeong Jin, Youngdo Jeong, Vincent M. Rotello   +5 more
doaj   +1 more source

Genetic Code Expansion and Click-Chemistry Labeling to Visualize GABA-A Receptors by Super-Resolution Microscopy

Frontiers in Synaptic Neuroscience, 2021
Fluorescence labeling of difficult to access protein sites, e.g., in confined compartments, requires small fluorescent labels that can be covalently tethered at well-defined positions with high efficiency.
Alexander Kuhlemann, Gerti Beliu, Gerti Beliu, Dieter Janzen, Enrica Maria Petrini, Danush Taban, Dominic A. Helmerich, Sören Doose, Martina Bruno, Andrea Barberis, Carmen Villmann, Markus Sauer, Christian Werner   +12 more
doaj   +1 more source

Correction: Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation

, 2018
Correction for ‘Clickable glutathione using tetrazine-alkene bioorthogonal chemistry for detecting protein glutathionylation’ by Dilini N. Kekulandara et al., Org. Biomol. Chem., 2016, 14, 10886–10893.
Kusal T. G. Samarasinghe, Young-Hoon Ahn, Dilini N. Kekulandara, Dhanushka N. P. Munkanatta Godage   +3 more
core   +1 more source

Celebrating the 2022 Nobel Prize in Chemistry. How are click chemistry and bioorthogonal chemistry transforming biomedicine? [PDF]

, 2023
La química clic i la química bioortogonal han obert nous camins en la modificació de sistemes complexos i han contribuït a posar la química a l’abast de tothom.
Oller-Salvia, Benjamí
core   +1 more source

Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry

Journal of the American Chemical Society, 2012
Mycobacteria, including the pathogen Mycobacterium tuberculosis, use the non-mammalian disaccharide trehalose as a precursor for essential cell-wall glycolipids and other metabolites. Here we describe a strategy for exploiting trehalose metabolic pathways to label glycolipids in mycobacteria with azide-modified trehalose (TreAz) analogues.
Swarts, Benjamin M, Holsclaw, Cynthia M, Jewett, John C, Alber, Marina, Fox, Douglas M, Siegrist, M Sloan, Leary, Julie A, Kalscheuer, Rainer, Bertozzi, Carolyn R   +8 more
openaire   +4 more sources

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Development and application of bond cleavage reactions in bioorthogonal chemistry

, 2016
Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have
Li, Jie, Chen, Peng R.
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source