Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
Molecules, 2021 Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron ...
Eunha Kim, Jonghoon Kim
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Tetrazine-based bioorthogonal reactions to image hypoxia in cancer cells [PDF]
iScienceSummary: Suboptimal oxygen supply in solid tumors controls a variety of cancer hallmarks and impairs responsiveness to anticancer treatments. Yet, tools to visualize hypoxia in cancer are still limited.
Sara Boumya +9 more
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Red light-responsive bioorthogonal chemistry enabled on-demand prodrug activation for cancer therapy [PDF]
Acta Pharmaceutica Sinica BLight-driven chemistry has revolutionized modern medicine, enabling precise disease detection and on-demand therapeutic interventions with high spatiotemporal accuracy. However, despite tremendous advances in bioorthogonal reactions, photoclick chemistry-
Hanzeng Cheng +15 more
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1,2,4,5‐Tetrazine‐Boron Halide Adduct Formation Unraveled in Solution and Solid State [PDF]
ChemistryOpen1,2,4,5‐Tetrazines are electron‐deficient heterocycles with four nitrogen atom‐localized lone pairs potentially acting as Lewis bases. While it has been shown that tetrazines, as electronically amphiphilic ligands, undergo anion–π, π–π, and transition ...
Jona Voss +5 more
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Non-specific cysteine modifications on proteins induced by trans-cyclooctene [PDF]
RSC Chemical BiologyTetrazine-trans-cyclooctene (Tz-TCO) click chemistry has been widely adopted for various applications due to its faster reaction kinetics and higher biocompatibility compared to conventional copper-catalyzed click chemistry. However, most click chemistry
Zhijian Yan, Wei Qin
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A novel 18F-labelled tetrazine ester prosthetic group for improved radiolabelling and in vivo stability of proteins and peptides [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Monoclonal antibodies, engineered protein scaffolds, and peptides are increasingly important in therapy and diagnostics owing to their high specificity and affinity.
Francesco Lechi +5 more
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MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]
Journal of IMAB, 2023 Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
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A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. [PDF]
PLoS ONE, 2016 A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image bone metabolism and bacterial infection using both active and pretargeting strategies was ...
Alyssa Vito +13 more
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Molecules, 2021 Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie +6 more
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IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications
Molecules, 2021 The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT).
Maryana Handula +2 more
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