Results 31 to 40 of about 7,204 (227)

Tetrazine ligation for chemical proteomics [PDF]

Proteome Science, 2016
Determining small molecule-target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class molecular tools. Chemical probes can provide great spatiotemporal control to elucidate biological functions of proteins as well as for ...
Kyungtae Kang, Jongmin Park, Eunha Kim
openaire   +3 more sources

Synthesis, thermal behaviors, and energetic properties of asymmetrically substituted tetrazine-based energetic materials

Frontiers in Chemistry, 2022
1,2,4,5-tetrazine ring is a common structure for the construction of energy-containing compounds, and its high nitrogen content and large conjugation effect give it the advantage of a good balance between energy and mechanical stability as a high ...
Shenghui Wang, Xiang Chen, Yuankai Chen, Hai Nan, Yuanyuan Li, Haixia Ma   +5 more
doaj   +1 more source

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

Pharmaceuticals, 2023
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez, Stéphane Guillouet, Yann Seimbille, Cécile Perrio   +3 more
doaj   +1 more source

Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry

Pharmaceutics, 2022
The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic factors to the wound, thereby stimulating regeneration over ...
Merel Gansevoort, Jona Merx, Elly M. M. Versteeg, Isidora Vuckovic, Thomas J. Boltje, Toin H. van Kuppevelt, Willeke F. Daamen   +6 more
doaj   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

Evaluation of Organo [¹⁸F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers

Molecules, 2020
Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled radiotracers often requires harsh reaction conditions, limiting the
Sofia Otaru, Surachet Imlimthan, Mirkka Sarparanta, Kerttuli Helariutta, Kristiina Wähälä, Anu J. Airaksinen   +5 more
doaj   +1 more source

Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive Trans-Cyclooctene [PDF]

, 2019
The high reaction rate of the \u27click-to-release\u27 reaction between allylic substituted trans-cyclooctene and tetrazine has enabled exceptional control over chemical and biological processes.
Raffaella, Rossin, Wolter ten, Hoeve, Freek J. M., Hoeben, Peter, J. Hudson, Marc, Robillard, Arthur, van Onzen, Ron M., Versteegen, Ivo A.W., Filot, Henk M., Janssen, tong, zhu, Jeremy, Wu   +10 more
core   +2 more sources

Tetrazine-Based Ligand Transformation Driving Metal–Metal Bond and Mixed-Valence Hg^I/Hg^II

, 2018
Understanding the self-assembly of cluster aggregates remains an important challenge in coordination chemistry. A chelating tetrazine-based ligand was employed to isolate an unprecedented tetranuclear Hg4 complex exhibiting HgI/HgII mixed valence, which ...
Muralee Murugesu (1431817), Bulat Gabidullin (4455532), Stephan N. Steinmann (1484704), Maykon A. Lemes (5703995), Hilarie N. Stein (5703998)   +4 more
core   +2 more sources

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs

Molecules, 2020
Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang, Chang Zhang, Haoxing Wu, Ping Feng   +3 more
doaj   +1 more source

Oxidative (3+3) Cycloaddition/Ring-Opening Reactions of Simple Urea Derivatives and N,N′‑Cyclic Azomethine Imines to Construct 1,2,3,5-Tetrazine-4(1H)‑one Derivatives

, 2023
A novel oxidative (3 + 3) cycloaddition/ring-opening reaction of N,N′-cyclic azomethine imines with the in situ generated diaza-oxylallyl cations from simple urea derivatives in the presence of base and PhI(OAc)2 has been developed.
Zhao-Lin He (1491004), Wen Tian (1697821), Wen Tian, Gang Wang, Gang Wang (36685), Zhao-Lin He   +5 more
core   +1 more source