Results 31 to 40 of about 9,278 (213)
Angewandte Chemie, EarlyView.Tuning the rate of covalent network formation in hybrid double network hydrogels regulates whether supramolecular filaments retain their low‐nm structures or depletion‐induced supramolecular assembly takes place forming bundles. This kinetic handle programs the mesoscale architecture and toughness of the hydrogels, establishing a link between ...
Mertcan Özel +7 more
wiley +2 more sources
Frontiers in Chemistry, 2022 1,2,4,5-tetrazine ring is a common structure for the construction of energy-containing compounds, and its high nitrogen content and large conjugation effect give it the advantage of a good balance between energy and mechanical stability as a high ...
Shenghui Wang +5 more
doaj +1 more source
Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine
Pharmaceuticals, 2023 The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez +3 more
doaj +1 more source
Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro [PDF]
, 2014 Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s).
Crot, Stéphanie +3 more
core +1 more source
Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
Pharmaceutics, 2022 The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic factors to the wound, thereby stimulating regeneration over ...
Merel Gansevoort +6 more
doaj +1 more source
Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. [PDF]
, 2020 In vivo compatible reactions have a broad range of possible applications in chemical biology and the pharmaceutical sciences. Here we report tetrazines that can be removed by exposure to isonitriles under very mild conditions.
Eckvahl, Hannah J +7 more
core
Molecules, 2020 Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled radiotracers often requires harsh reaction conditions, limiting the
Sofia Otaru +5 more
doaj +1 more source
Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
doaj +1 more source
Excited State Geometry of and Radiationless Processes in the Lowest B3u(nπ*) Singlet State of s-Tetrazine [PDF]
, 1974 High resolution absorption and laser-induced emission spectra of the lowest B3u(nπ*) singlet state of s-tetrazine-h2 and -d2 in a benzene crystal at 1.8 K are presented and discussed. The absorption spectrum with origin at 17231 cm-1 (h2) is dominated by
Meyling, J.H., Werf, R.P. van der
core +1 more source
Tetrazine ligation for chemical proteomics [PDF]
Proteome Science, 2016 Determining small molecule-target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class molecular tools. Chemical probes can provide great spatiotemporal control to elucidate biological functions of proteins as well as for ...
Kyungtae Kang, Jongmin Park, Eunha Kim
openaire +3 more sources