Results 41 to 50 of about 7,204 (227)

Tetrazine-Derived Near-Infrared Dye for Targeted Photoacoustic Imaging of Bone

, 2023
A near-infrared photoacoustic probe was used to image bone in vivo through active and bioorthogonal pretargeting strategies that utilized coupling between a tetrazine-derived cyanine dye and a trans-cyclooctene-modified bisphosphonate.
Saman Sadeghi (1912072), Samantha Slikboer (1573096), Amber Faraday (9188874), Saman Sadeghi, John F. Valliant (1428703), Nancy Janzen (1428712), Rowan Swann, John F. Valliant, Amber Faraday, Afaf Genady (3761452), Nancy Janzen, Afaf Genady, Samantha Slikboer, Luis Rafael Silva, Luis Rafael Silva (15366669), Rowan Swann (9188886)   +15 more
core   +2 more sources

Synthesis and crystal structure of 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate

Acta Crystallographica Section E: Crystallographic Communications
An orthogonally addressable 3,6-disubstituted 1,2,4,5-tetrazine, namely 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate (C14H14Cl3N5O3), was synthesized and characterized by single-crystal X-ray diffraction.
J. Voss, H.G. Stammler, N. Sewald
doaj   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics [PDF]

Chembiochem
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Taylor N, de Sousa‐Lourenço J, Nikić‐Spiegel I.   +2 more
europepmc   +2 more sources

Biomedical Applications of Tetrazine Cycloadditions [PDF]

Accounts of Chemical Research, 2011
Disease mechanisms are increasingly being resolved at the molecular level. Biomedical success at this scale creates synthetic opportunities for combining specifically designed orthogonal reactions in applications such as imaging, diagnostics, and therapy.
Devaraj, Neal K., Weissleder, Ralph
openaire   +4 more sources

Synthesis, antibacterial and antibiofilm activity of new 1,2,3,5-tetrazine derivatives from coupling reactions of diazonium salt of 2-amino-6-nitrobenzothiazole with diverse substituted 2-aminobenzothiazole derivatives

Acta Chimica Slovenica
The coupling reaction of diazonium ion of 2-amino-6-nitrobenzothiazole at 0-5 °C with distinctly substituted 2-aminobenzothiazole derivatives produced new 1,2,3,5-tetrazine derivatives.
Joseph Tsemeugne, Yetiny Atuh Bah, Ulrich Joel Tsopmene, Armelle Tontsa Tsamo, Jérôme Ndefo Ndefonganga, Pierre Mkounga, Emmanuel Fondjo Sopbué, Jean Paul Dzoyem, Augustin Ephrem Nkengfack   +8 more
doaj   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

1-[6-(3,5-Dimethylpyrazol-1-yl)-1,2,4,5-tetrazin-3-yl]guanidin-2-ium perchlorate methanol monosolvate

Acta Crystallographica Section E, 2013
In the title solvated salt, C8H12N9+·ClO4−·CH3OH, the dihedral angle between the tetrazine and pyrazole rings is 26.05 (7)°.
Hai-Xia Ma, Jie Li, Biao Yan, Yong-Peng Hu   +3 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Synthesis scheme for ^99mTc-HYNIC-tetrazine-TCO-vancomycin (7) from TCO-vancomycin (6) and 4.

, 2016
Synthesis scheme for 99mTc-HYNIC-tetrazine-TCO-vancomycin (7) from TCO-vancomycin (6) and 4.
Megan Blacker (1428724), John F. Valliant (1428703), Nancy Janzen (1428712), Afaf R. Genady (1566097), Lisset Llano (3390371), Alyssa Vito (1428727), Stephanie Rathmann (3390380), Paul J. Berti (2056342), Zoya Naperstkow (3390386), Hussain Alarabi (3390383), Omid Beiraghi (3390377), Salma A. Alkarmi (3390374), Shannon Czorny (1655416), Jeff Kent (1929649)   +13 more
core   +1 more source

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

Molecules, 2022
The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal ...
Xueli Zhang, Amu Gubu, Jianfei Xu, Ning Yan, Wenbo Su, Di Feng, Qian Wang, Xinjing Tang   +7 more
doaj   +1 more source