Results 41 to 50 of about 9,278 (213)

Synthesis and crystal structure of 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate

Acta Crystallographica Section E: Crystallographic Communications
An orthogonally addressable 3,6-disubstituted 1,2,4,5-tetrazine, namely 2,2,2-trichloroethyl N-{4-[6-(1-hydroxyethyl)-1,2,4,5-tetrazin-3-yl]benzyl}carbamate (C14H14Cl3N5O3), was synthesized and characterized by single-crystal X-ray diffraction.
J. Voss, H.G. Stammler, N. Sewald
doaj   +1 more source

1-[6-(3,5-Dimethylpyrazol-1-yl)-1,2,4,5-tetrazin-3-yl]guanidin-2-ium perchlorate methanol monosolvate

Acta Crystallographica Section E, 2013
In the title solvated salt, C8H12N9+·ClO4−·CH3OH, the dihedral angle between the tetrazine and pyrazole rings is 26.05 (7)°.
Hai-Xia Ma, Jie Li, Biao Yan, Yong-Peng Hu   +3 more
doaj   +1 more source

Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines [PDF]

, 2018
We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials.
A Kuzmin, AG Kolhatkar, Alexandru Chivu, AM Morawski, BL Oliveira, CS McKay, DMM Jaradat, F Herranz, HL Evans, JB Haun, JM Baskin, JR Dunetz, Juan C. Kaski, M Colombo, M Ohgushi, Marco M. Meloni, MF Debets, MM Meloni, NK Devaraj, RA Trivedi, SA Schmitz, SK Mishra, Stephen Barton, Taigang He, Wenhui Song   +24 more
core   +3 more sources

Synthesis, antibacterial and antibiofilm activity of new 1,2,3,5-tetrazine derivatives from coupling reactions of diazonium salt of 2-amino-6-nitrobenzothiazole with diverse substituted 2-aminobenzothiazole derivatives

Acta Chimica Slovenica
The coupling reaction of diazonium ion of 2-amino-6-nitrobenzothiazole at 0-5 °C with distinctly substituted 2-aminobenzothiazole derivatives produced new 1,2,3,5-tetrazine derivatives.
Joseph Tsemeugne, Yetiny Atuh Bah, Ulrich Joel Tsopmene, Armelle Tontsa Tsamo, Jérôme Ndefo Ndefonganga, Pierre Mkounga, Emmanuel Fondjo Sopbué, Jean Paul Dzoyem, Augustin Ephrem Nkengfack   +8 more
doaj   +1 more source

Synthesis and properties of a promising high energy and low impact sensitivity explosive: hydroxylammonium 3-hydrazino-6-(1H-1,2,3,4-tetrazol-5-ylimino)-s-tetrazine

FirePhysChem, 2023
Tetrazine compounds, especially their energetic salts, show good application prospect in high-performing energetic materials (EMs). Among them, the hydroxylammonium salt show the best energetic properties.
Zihan Zhang, Xiang Chen, Yuankai Chen, Yuanyuan Li, Hai Nan, Haixia Ma   +5 more
doaj   +1 more source

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis [PDF]

, 2014
The need for post-synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents.
Emmetiere, Fabien, Lewis, Jason S, Pillarsetty, Nagavarakishore, Reiner, Thomas, Weissleder, Ralph, Zeglis, Brian M   +5 more
core   +1 more source

Biomedical Applications of Tetrazine Cycloadditions [PDF]

Accounts of Chemical Research, 2011
Disease mechanisms are increasingly being resolved at the molecular level. Biomedical success at this scale creates synthetic opportunities for combining specifically designed orthogonal reactions in applications such as imaging, diagnostics, and therapy.
Devaraj, Neal K., Weissleder, Ralph
openaire   +3 more sources

Rational design for high bioorthogonal fluorogenicity of tetrazine‐encoded green fluorescent proteins

Natural Sciences, 2022
The development of bioorthogonal fluorogenic probes constitutes a vital force to advance life sciences. Tetrazine‐encoded green fluorescent proteins (GFPs) show high bioorthogonal reaction rate and genetic encodability but suffer from low fluorogenicity.
Longteng Tang, Riley M. Bednar, Nikita D. Rozanov, Marcus L. Hemshorn, Ryan A. Mehl, Chong Fang   +5 more
doaj   +1 more source

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

Molecules, 2022
The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal ...
Xueli Zhang, Amu Gubu, Jianfei Xu, Ning Yan, Wenbo Su, Di Feng, Qian Wang, Xinjing Tang   +7 more
doaj   +1 more source

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source