Results 61 to 70 of about 7,204 (227)

Über das 1.2.4.5‐Tetrazin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1907
n ...
Curtius, T.-H., Darapsky, August, Müller, Ernst   +2 more
openaire   +1 more source

Tetrazine-Mediated Bioorthogonal System for Prodrug Activation, Photothermal Therapy, and Optoacoustic Imaging

, 2019
Bioorthogonal “bond cleavage” reactions hold great promise in a variety of biological applications such as controlled activation of the drug and probe, while the application of these biocompatible reactions in living animals is still in its infancy and ...
Bowen Li (200859), Jie Wang (16762), Shuizhu Wu (1428475), Xin xie (7598333), Chenyue Zhan (5523617), Yong Huang (15745), Fang Zeng (199535)   +6 more
core   +1 more source

Synthese einer Stabilen, Hydrophilen Trans‐Cycloocten‐Aminosäure Ermöglicht Schnelle Bioorthogonale Klick‐Chemie zur Herstellung von Antikörper‐Wirkstoffkonjugaten Mittels Erweiterung des Genetischen Codes

Angewandte Chemie, EarlyView.
Es wird von einer neuen trans‐Cycloocten (TCO) basierten nicht‐kanonischen Aminosäure (ncAA) berichtet, die von einer hohen Hydrophilizität und bemerkenswerter Stabilität gegen trans‐cis‐Isomerisierung charakterisiert ist. Der Einbau dieser mittels Erweiterung des genetischen Codes in einen Antikörper und nachfolgende Konjugation erzeugte ein ...
Georgi R. Genov, Dina Osmanović, Ines Bašić, Christine Koehler, Paul F. Sauter   +4 more
wiley   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Functionalization and Crosslinking of Reduced Graphene Oxide Sheets by Multiple Tetrazine Units to Improve the Energy Storage in Supercapacitors

ChemElectroChem
A multi‐tetrazine compound tailored for grafting on graphene sheets has been designed and investigated. It is composed of hydrogen substituted tetrazines involved in inverse Diels‐Alder demand cycloaddition reactions for grafting and a central ...
Dr. Margarita Bosmi, Ademola Adeniji, Elise Michel, Arnaud Brosseau, Dr. Vitor Brasiliense, Prof. Pierre Audebert, Dr. Remith Pongilat, Dr. Magali Gauthier, Prof. Fabien Miomandre   +8 more
doaj   +1 more source

Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation [PDF]

, 2018
Mild oxidation of dihydrogen tetrazine by horseradish peroxidase was utilised in bioorthogonal crosslinking, via tetrazine–norbornene ligation, of polyethylene glycol–gelatin hydrogels.
J. E. Frith, Carthew, J., J. S. Forsythe, V. X. Truong, Forsythe, J. S., J. Carthew, Truong, V. X., Frith, J. E.; id_orcid   +7 more
core   +1 more source

Poly[(μ2-3,6-di-4-pyridyl-1,2,4,5-tetrazine)(μ2-thiocyanato)copper(I)]

Acta Crystallographica Section E, 2010
The title compound, [Cu(NCS)(C12H8N6)]n, is a self-assembled two-dimensional metal–organic network. The Cu atom is linked by two N atoms from two 3,6-di-4-pyridyl-1,2,4,5-tetrazine ligands and by the N and S atoms from two thiocyanate ligands ...
Yiming Wu, Qinglong Meng, Chi Zhang
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

DFT-based reactivity and combined QSAR, molecular docking of 1,2,4,5-Tetrazine derivatives as inhibitors of Pim-1 kinase

Heliyon, 2019
In the present work we have calculated several DFT reactivity descriptors for 1,2,4,5-Tetrazine at the B3LYP/6–311++G(d,p) level of theory in order to analyze its reactivity in vacuum and solvent phases.
Halima Hazhazi, Nadjib Melkemi, Toufik Salah, Mohammed Bouachrine   +3 more
doaj   +1 more source

Development of new tools for the tetrazine ligation: installation of minimal tetrazines through silver(i) mediated cross-coupling and development of a hydrophilic trans-5-oxocene for bioorthogonal labeling

, 2023
Fox, Joseph M.Methods to probe the biochemistry of living organisms have been greatly augmented by the relatively recent advancement of bioorthogonal chemistry.
Lambert, William D.
core   +1 more source