Results 71 to 80 of about 7,204 (227)
Angewandte Chemie International Edition, EarlyView.A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov +4 more
wiley +1 more source
Metabolic glycan imaging by isonitrile-tetrazine click chemistry. [PDF]
, 2019 Seeing the sugar coating: N-Acetyl-glucosamine and mannosamine derivatives tagged with an isonitrile group are metabolically incorporated into cell-surface glycans and can be detected with a fluorescent tetrazine.
core +2 more sources
Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
, 2011 Bis(cyclohexylmethyl) 3,6-bis(4-chlorophenyl)-1,2,4,5-tetrazine-1,2-dicarboxylate was prepared from cyclohexylmethyl chloroformate and 3,6-bis(4-chlorophenyl)-1,2(or 1,4)-dihydro-1,2,4,5-tetrazine and its structure was determined by X-ray diffraction ...
Xiao-Guang Mao +3 more
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Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source
Nanoparticle “switch-on” by tetrazine triggering
Chem. Commun., 2016 This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations.
Kevin Neumann +3 more
openaire +3 more sources
The role of 1,2,4,5-tetrazine rings in π–π stacking interactions
, 2003 The crystal structures of 3,6-dipyridin-3-yl-(1,2,4,5)-tetrazine, 3,6-dipyridin-4-yl-(1,2,4,5)-tetrazine and 3,6-dipyrazin-2-yl-(1,2,4,5)-tetrazine are reported.
Champness, Neil R. +6 more
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Applied SciencesNitrogen-rich heterocycles constitute a family of high energy density materials (HEDMs) that have been developing intensively in recent years. A representative of this class is 1,2,4,5-tetrazine, a six-membered aromatic compound containing four nitrogen ...
Sebastian Górecki, Agnieszka Kudelko
doaj +1 more source
Expanding the Scope of Indium in Frustrated Lewis Pair Chemistry
Chemistry – A European Journal, EarlyView.All good things come in threes: The pyridine‐“protected” FLP tBu2InCH2PtBu2·Py shows three different kinds of reactivity: Besides “typical” FLP activity, it prefers formation of the “soft” isomers for substrates with multiple sites for FLP attack, but reacts with SO2 as a “masked” In/C FLP by insertion into the In─C bond.
Daniel N. Heuer +5 more
wiley +1 more source
Spectroscopic and photochemical investigation of s-tetrazine. [PDF]
, 1968 Raman scattering, fluorescence, visible absorption, ultraviolet absorption, and infrared absorption spectra of s-tetrazine-d and s-tetrazine-d„ were observed. Previously o 2. unreported fundamental vibrational bands were found.
Kimble, Charles Donald
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