Results 71 to 80 of about 9,278 (213)
Heliyon, 2019 In the present work we have calculated several DFT reactivity descriptors for 1,2,4,5-Tetrazine at the B3LYP/6–311++G(d,p) level of theory in order to analyze its reactivity in vacuum and solvent phases.
Halima Hazhazi +3 more
doaj +1 more source
A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]
, 2012 The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Garelnabi, EAE +7 more
core +1 more source
Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers
Chemistry – A European Journal, EarlyView.Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley +1 more source
ChemElectroChemA multi‐tetrazine compound tailored for grafting on graphene sheets has been designed and investigated. It is composed of hydrogen substituted tetrazines involved in inverse Diels‐Alder demand cycloaddition reactions for grafting and a central ...
Dr. Margarita Bosmi +8 more
doaj +1 more source
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
Pharmaceuticals, 2023 To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for ...
Chiara Timperanza +4 more
doaj +1 more source
Enzymatic Cross-Linking of Dynamic Thiol-Norbornene Click Hydrogels [PDF]
, 2019 Enzyme-mediated in situ forming hydrogels are attractive for many biomedical applications because gelation afforded by enzymatic reactions can be readily controlled not only by tuning macromer compositions, but also by adjusting enzyme kinetics.
Hudson, Britney N. +3 more
core +2 more sources
Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality
Chemistry – A European Journal, EarlyView.Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim +3 more
wiley +1 more source
1,3,4,6-Tetramethyl-1,4-dihydro-1,2,4,5-tetrazine, C_6H_(12)N_4 [PDF]
, 1984 M_r =140∙19, monoclinic, P2_1/n, a = 10∙612(3), b=6∙820(1), c= 10∙975 (2) Å, β=95∙31(2)°, V=790.9(5) Å^3, Z=4, D_m=1.13(5) (flotation), D_x = 1∙177 g cm^(-3), Mo Kα, λ = 0.71073 Å, μ= 0.848 cm^(-1), F(000) = 304, T= 295 K, R = 0∙077 for 704 observed ...
Bemis, Guy W. +3 more
core
Synthesis of 3,6-Divinyl-1,2,4,5-Tetrazine, the First Member of the Elusive Vinyltetrazine Family [PDF]
, 2009 International audienceThe synthesis of the first vinyltetrazine derivative is described. 3,6-Divinyl-1,2,4,5-tetrazine was obtained following a methodology involving cyclization from an imidate and use of 2-phenylsulfonylethyl groups as masked vinyl ...
Beller, Lionel +6 more
core +3 more sources
EcoEnergy, EarlyView.This review systematically compares photocatalytic urea synthesis from various C (CO2, CO, CH3OH) and N (N2, NH3, NO3−) sources. It highlights C–N coupling mechanisms, key challenges, and future directions, offering a framework to guide rational catalyst design for sustainable, solar‐driven urea production.
Bo Ding +5 more
wiley +1 more source