Improvement of radioimmunotherapy using pretargeting [PDF]
Frontiers in Oncology, 2013 During the past two decades, considerable research has been devoted to radionuclide therapy using radiolabelled monoclonal antibodies and receptor binding agents.
Eric eFrampas +10 more
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Clearing and Masking Agents in Pretargeting Strategies [PDF]
Pharmaceuticals, 2023 ‘Pretargeting’ led to increased target-to-background ratios of nanomedicines in short timeframes. However, clearing or masking agents are needed to reach the full potential of pretargeted approaches.
Markus Staudt, Matthias M. Herth
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Pretargeted Molecular Imaging and Radioimmunotherapy [PDF]
Theranostics, 2012 Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the ...
David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey
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Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]
EJNMMI Research, 2017 Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Outi Keinänen +9 more
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Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211 [PDF]
Pharmaceuticals, 2023 To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for ...
Chiara Timperanza +4 more
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Modified poly-L-lysine for use as a clearing agent in pretargeted radioimmunotherapy [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Pretargeted radioimmunotherapy of cancer has the potential to increase tumor specific uptake of activity when compared with conventional radioimmunotherapy.
Chiara Timperanza +5 more
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A Bioorthogonal TCO–Tetrazine-Based Pretargeted PET/NIRF Platform Enabling High-Contrast Tumor Imaging [PDF]
PharmaceuticalsObjectives: Pretargeting strategies enhance the specificity and safety of radiopharmaceuticals by separating tumor targeting from radionuclide delivery. To address the rapid clearance and systemic exposure of directly labeled small-molecule agents, a DZ ...
Mingxing Huang +9 more
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A peptide nucleic acid-based pretargeting approach using 161Tb for radionuclide therapy in a murine tumor model [PDF]
EJNMMI ResearchBackground Although molecular tumor-targeting peptides modified with albumin-binding domains can enhance tumor probe uptake and prolong tumor retention time, the prolonged systemic circulation resulting from this modification also increases radiation ...
Hongcheng Li +9 more
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Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies [PDF]
PharmaceuticalsRadiolabeled antibodies are powerful tools for both imaging and therapy in the field of nuclear medicine. Radiolabeling methods that do not release radionuclides from parent antibodies are essential for radiolabeling antibodies, and practical ...
Hiroyuki Suzuki +2 more
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In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with astatine-211 [PDF]
EJNMMI Radiopharmacy and ChemistryBackground A significant challenge in cancer therapy lies in eradicating hidden disseminated tumor cells. Within Nuclear Medicine, Targeted Alpha Therapy is a promising approach for cancer treatment tackling disseminated cancer.
Chiara Timperanza +5 more
doaj +2 more sources