Results 31 to 40 of about 2,392 (196)

Eleven-year experience with the avidin-biotin pretargeting system in glioblastoma: Toxicity, efficacy and survival [PDF]

, 2012
Background: The 3-step avidin-biotin pretargeting approach is applied in patients with recurrent glioblastoma (GBM), using biotinylated anti-tenascin monoclonal antibody as the first step of pretargeting followed by avidin and 90Ybiotin.
Baio, Silvia M., Bartolomei, Mirco, Bodei, Lisa, Broggi, Giovanni, Chinol, Marco, Cremonesi, Marta, De Cicco, Concetta, Grana, Chiara M., Pacifici, Monica, Paganelli, Giovanni, Rocca, Paola A., Severi, Stefano, Tiberini, Simone   +12 more
core   +2 more sources

Pretargeted Theranostics

, 2021
Personalized medicine is becoming an integral part of our healthcare system, in which theranostics play a fundamental role. Nanomedicines such as monoclonal antibodies are a commonly used targeting vector in such approaches due to their outstanding targeting abilities as well as their capabilities to function as drug delivery vehicles.
Markus, Staudt,, M., Herth, tthias, B.M., Poulie, Christian   +2 more
openaire   +2 more sources

Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting

Pharmaceutics, 2021
Atherosclerosis is a chronic progressive disease involving inflammatory events, such as the overexpression of adhesion molecules including the endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1).
Sara Pastorino, Sara Baldassari, Giorgia Ailuno, Guendalina Zuccari, Giuliana Drava, Andrea Petretto, Vanessa Cossu, Cecilia Marini, Silvana Alfei, Tullio Florio, Gianmario Sambuceti, Gabriele Caviglioli   +11 more
doaj   +1 more source

Pretargeted Radioimmunotherapy for B-Cell Lymphomas [PDF]

Clinical Cancer Research, 2007
Abstract Relapsed or treatment refractory B-cell lymphomas are currently incurable with conventional chemotherapy and radiation treatments. High-dose chemoradiotherapy and stem cell transplantation can cure some patients with relapsed or refractory lymphoma, but the majority of such patients die of progressive disease.
Damian J, Green, John M, Pagel, Anastasia, Pantelias, Nathan, Hedin, Yukang, Lin, D Scott, Wilbur, Ajay, Gopal, Donald K, Hamlin, Oliver W, Press   +8 more
openaire   +2 more sources

Pretargeted radioimmunoimaging with a biotinylated D-D construct and Tc-DTPA-biotin: strategies for early diagnosis of small cell lung cancer

Journal of International Medical Research, 2020
Objective Pro-gastrin releasing peptide (ProGRP) plays an oncogenic role in small cell lung cancer (SCLC). The anti-ProGRP (31-98) monoclonal antibody D-D 3 can selectively accumulate in SCLC xenografts in nude mice.
Zhihui Hong, Shengming Deng, Yizhen Shi, Yichi Xie, Jiaxi You, Wei Wang, Hong Huang, Zengli Liu   +7 more
doaj   +1 more source

Construction of single-chain variable fragment antibodies against MCF-7 breast cancer cells. [PDF]

, 2013
A phage display library of single chain variable fragment (scFv) against MCF-7 breast cancer cells was constructed from C3A8 hybridoma cells. RNA from the C3A8 was isolated, cDNA was constructed, and variable heavy and light immunoglobulin chain gene ...
Ahmad, Zuhaida Asra, Ali, Abdul Manaf, Hamid, Muhajir, Mohamed Alitheen, Noorjahan Banu, Noor, A. M., Subramani, Tamilselvan, Yeap, Swee Keong   +6 more
core   +1 more source

A Semiempirical Model of Tumor Pretargeting [PDF]

Bioconjugate Chemistry, 2008
This article provides an overview of a semiempirical pretargeting model now under development. After a brief review of the pretargeting concept, the strategies available, and the complexities of optimizing the dosage and timing, a semiempirical model is described that is not only capable of optimizing dosage and timing but also capable of predicting ...
Guozheng, Liu, Donald J, Hnatowich
openaire   +2 more sources

A pretargeting system for tumor PET imaging and radioimmunotherapy

Frontiers in Pharmacology, 2015
Labeled antibodies, as well as their fragments and antibody-derived recombinant constructs, have long been proposed as general vectors to target radionuclides to tumor lesions for imaging and therapy.
Françoise eKraeber-Bodéré, Caroline eRousseau, Caroline eBodet-milin, Eric eFrampas, Alain eFaivre-Chauvet, Aurore eRauscher, Robert eSharkey, David eGoldenberg, Jean-Francois eChatal, Jacques eBarbet, Jacques eBarbet   +10 more
doaj   +1 more source

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [PDF]

, 2015
Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity ...
Carrasquillo, Jorge A., Chalasani, Sandhya, Cheal, Sarah M., Cheung, Nai-Kong V., Fung, Edward K., Guo, Hong-fen, Jungbluth, Achim, Larson, Steven M., Lee, Sang-gyu, O’Donoghue, Joseph, Punzalan, Blesida, Smith-Jones, Peter M., Wittrup, Karl Dane, Xu, Hong, Zanzonico, Pat B.   +14 more
core   +1 more source

Novel DNA Polymer for Amplification Pretargeting [PDF]

ACS Medicinal Chemistry Letters, 2015
In this Letter, different from conventional pretargeting, an additional novel DNA polymer with multiple copies of a target was first designed to be administrated between the antitumor antibody, and the labeled effector served as an amplification pretargeting strategy.
Liang, Xiaoshan, Huang, Qingqing, Xiao, Jie, Liu, Guozheng, Dou, Shuping, Rusckowski, Mary, Shi, Hongcheng, Liu, Yuxia, Cheng, Dengfeng   +8 more
openaire   +3 more sources