Results 21 to 30 of about 2,392 (196)
Pharmaceuticals, 2022 Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies.
Christoph Bredack +4 more
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Theranostic Pretargeting Drug Delivery and Imaging Platforms in Cancer Precision Medicine
Frontiers in Oncology, 2020 Theranostics are nano-size or molecular-level agents serving for both diagnosis and therapy. Structurally, they are drug delivery systems integrated with molecular or targeted imaging agents.
Sudath Hapuarachchige +2 more
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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET
EJNMMI Radiopharmacy and Chemistry, 2022 Background Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-lived PET isotopes, while reducing
Hugo Helbert +11 more
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Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?
Pharmaceuticals, 2022 Pretargeting is a promising nuclear imaging technique that allows for the usage of antibodies (Abs) with enhanced imaging contrast and reduced patient radiation burden. It is based on bioorthogonal chemistry with the tetrazine ligation—a reaction between
Sara Lopes van den Broek +9 more
doaj +1 more source
Pharmaceutics, 2022 Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Because TNBC lacks the expression of commonly targeted receptors, it is challenging to develop a new imaging ...
Abhinav Bhise +13 more
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Pretargeting for imaging and therapy in oncological nuclear medicine
EJNMMI Radiopharmacy and Chemistry, 2017 Background Oncological pretargeting has been implemented and tested in several different ways in preclinical models and clinical trials over more than 30 years.
Clément Bailly +5 more
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Pretargeted imaging and radioimmunotherapy of cancer using antibodies and bioorthogonal chemistry
Frontiers in Medicine, 2014 Selective delivery of radionuclides to tumors may be accomplished using a two-step approach, in which in the first step the tumor is pretargeted with an unlabeled antibody construct and in the second step the tumor is targeted with a radiolabeled small ...
Otto C. Boerman
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Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha [PDF]
, 2010 PURPOSE: Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumour progression. For the imaging of HIF-1-active tumours, we previously developed a protein, POS, which is effectively delivered to and selectively stabilized in HIF-1 ...
Hiraoka, Masahiro +10 more
core +1 more source
A Revisit to the Pretargeting Concept—A Target Conversion
Frontiers in Pharmacology, 2018 Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to non-tumor ratios than direct-targeting using radiolabeled antibody.
Guozheng Liu
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IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications
Molecules, 2021 The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT).
Maryana Handula +2 more
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