Results 41 to 50 of about 2,392 (196)
A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery
Bioactive Materials, 2020 This work details a newly developed “sandwich” nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation. First, biotinylated- and folate-conjugated optical imaging micelles targeted activated macrophages via folate ...
Min Kyung Khang +4 more
doaj +1 more source
Frontiers in Medicine, 2019 Monoclonal antibody (mAb)-based therapies have experienced considerable growth in cancer management. When labeled with radionuclides, mAbs also represent promising probes for imaging or theranostic approaches.
Caroline Bodet-Milin +24 more
doaj +1 more source
Molecules, 2021 Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie +6 more
doaj +1 more source
Effect of Small-Molecule-Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody [PDF]
, 2012 Small-molecule ligands specific for tumor-associated surface receptors have wide applications in cancer diagnosis and therapy. Achieving high-affinity binding to the desired target is important for improving detection limits and for increasing ...
Frangioni, John V. +4 more
core +1 more source
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
Pharmaceutics, 2022 Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity
Alice D’Onofrio +9 more
doaj +1 more source
Biotin-streptavidin-guided two-step pretargeting approach using PLGA for molecular ultrasound imaging and chemotherapy for ovarian cancer [PDF]
PeerJ, 2021 Background Ovarian cancer seriously threatens the lives and health of women, and early diagnosis and treatment are still challenging. Pre-targeting is a promising strategy to improve the treatment efficacy of ovarian cancer and the results of ultrasound ...
Hang Zhou +8 more
doaj +2 more sources
In vivo 212Pb/212Bi generator using indium-DTPA-tagged liposomes [PDF]
, 2011 International audienceIndium-DTPA-tagged liposomes were studied in the present work as carriers of in vivo 212Pb / 212Bi generator to be used in targeted alpha therapy.
Barbet, J. +6 more
core +3 more sources
Chapter Pretargeted Theranostics [PDF]
, 2021 undefined
Herth, Matthias +2 more
openaire +2 more sources
Radionuclide Delivery Strategies in Tumor Treatment: A Systematic Review
Current Issues in Molecular Biology, 2022 The aim of this review was to assess recent progress in targeted radionuclide tumor therapy, focusing on the best delivery strategies. A literature search was conducted in PubMed, Web of Science, and Scopus using the terms “radionuclides”, “liposomes ...
Giulia Poletto +5 more
doaj +1 more source
Diabody Pretargeting with Click Chemistry In Vivo [PDF]
Journal of Nuclear Medicine, 2015 Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because of high renal radiometal retention. Therefore, we developed and evaluated a pretargeting strategy using click chemistry in vivo to reduce kidney uptake and avoid unwanted radiation ...
Duijnhoven, S.M.J. van +5 more
openaire +3 more sources