Results 51 to 60 of about 2,392 (196)
Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core +2 more sources
Development of 18F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging
Pharmaceuticals, 2022 Pretargeted PET imaging is an emerging and fast-developing method to monitor immuno-oncology strategies. Currently, tetrazine ligation is considered the most promising bioorthogonal reaction for pretargeting in vivo.
Rocío García-Vázquez +7 more
doaj +1 more source
Dendrimers in gene delivery [PDF]
, 2005 Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine +2 more
core +1 more source
Arginine, a Key Residue for the Enhancing Ability of an Antifreeze Protein of the Beetle Dendroides canadensis [PDF]
, 2009 Antifreeze proteins (AFPs) can produce a difference between the nonequilibrium freezing point and the melting point, termed thermal hysteresis (TH). The TH activity of an antifreeze protein (AFP) depends on the specific AFP and its concentration as well ...
Amornwittawat, Natapol +7 more
core +2 more sources
Bevacizumab radioimmunotherapy (RIT) with accelerated blood clearance using the avidin chase [PDF]
, 2018 学位記番号 ...
RYAN, YUDISTIRO +1 more
core
Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality
Chemistry – A European Journal, EarlyView.Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim +3 more
wiley +1 more source
Targeted Therapies for Each Subtype of Breast Cancer
MedComm, Volume 7, Issue 4, April 2026.This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu +5 more
wiley +1 more source
Exploring Structural Parameters for Pretargeting Radioligand Optimization [PDF]
Journal of Medicinal Chemistry, 2017 Pretargeting offers a way to enhance target specificity while reducing off-target radiation dose to healthy tissue during payload delivery. We recently reported the development of an 18F-based pretargeting strategy predicated on the inverse electron demand Diels-Alder reaction as well as the use of this approach to visualize pancreatic tumor tissue in ...
Jan-Philip Meyer +7 more
openaire +2 more sources
Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer
Cancer Innovation, Volume 5, Issue 1, February 2026.Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan +3 more
wiley +1 more source
Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies
Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley +1 more source